Publication Name	World Journal of Diabetes
Manuscript ID	31210
Country	United States

Received	2016-11-04 08:50
Peer-Review Started	2016-11-06 14:26
To Make the First Decision	2016-11-30 09:03
Return for Revision	2016-11-30 14:44
Revised	2017-02-17 23:38
Second Decision	2017-04-24 17:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-05 15:55
Articles in Press	2017-05-05 15:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-04 07:22
Publish the Manuscript Online	2017-06-15 02:07

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Statin use and cognitive function in middle-aged adults with type 1 diabetes
Manuscript Source	Invited Manuscript
All Author List	Karen A Nunley, Trevor J Orchard, Christopher M Ryan, Rachel Miller, Tina Costacou and Caterina Rosano
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK) R01 DK089028, PI (to Rosano C) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK) R37 DK034818-25, PI (to Orchard TJ) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK) R21 DK082900, PI (to Costacou T)
Corresponding Author	Karen A Nunley, PhD, MS, Visiting Assistant Research Professor, Department of Epidemiology, University of Pittsburgh, 5138 South Parran Hall, 130 N De Soto St., Pittsburgh, PA 15213, United States. kan62@pitt.edu
Key Words	Type 1 diabetes; Cognitive impairment; Memory; Statin use; Cohort study
Core Tip	Animal and cell culture studies show that statins can damage cerebral gray and white matter, thereby affecting cognitive function. Findings from human studies remain controversial; early observational studies reported that statin use negatively affected cognition, especially memory, while more recent studies have not replicated these findings. Even though statins are widely prescribed for people with type 1 diabetes (T1D), only one study to date has examined whether statin use is related to cognitive impairment in this patient population. We propose that deleterious effects statins may exert on cognition may be more pronounced in people with T1D, as these individuals are already at an increased risk of cognitive impairment due to long-term exposure to metabolic dysregulation.
Publish Date	2017-06-15 02:07
Citation	Nunley KA, Orchard TJ, Ryan CM, Miller R, Costacou T, Rosano C. Statin use and cognitive function in middle-aged adults with type 1 diabetes. World J Diabetes 2017; 8(6): 286-296
URL	http://www.wjgnet.com/1948-9358/full/v8/i6/286.htm
DOI	http://dx.doi.org/10.4239/wjd.v8.i6.286

Full Article (PDF)	WJD-8-286.pdf
Full Article (Word)	WJD-8-286.doc
Manuscript File	31210-Review.docx
Answering Reviewers	31210-Answering reviewers.pdf
Audio Core Tip	31210-Audio core tip.mp3
Biostatistics Review Certificate	31210-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31210-Conflict-of-interest statement.pdf
Copyright License Agreement	31210-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	31210-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	31210-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	31210-Institutional review board statement.pdf
Peer-review Report	31210-Peer-review(s).pdf
Scientific Misconduct Check	31210-Scientific misconduct check.pdf
Scientific Editor Work List	31210-Scientific editor work list.pdf