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7/21/2017 3:51:25 AM | Browse: 1245 | Download: 2029
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Received |
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2016-11-09 08:42 |
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Peer-Review Started |
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2016-11-10 15:46 |
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To Make the First Decision |
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2017-02-15 09:55 |
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Return for Revision |
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2017-02-16 14:00 |
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Revised |
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2017-02-21 01:58 |
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Second Decision |
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2017-03-02 16:25 |
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Accepted by Journal Editor-in-Chief |
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2017-03-04 09:24 |
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Accepted by Company Editor-in-Chief |
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2017-03-13 12:19 |
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Articles in Press |
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2017-03-13 12:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-07-18 08:47 |
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Publish the Manuscript Online |
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2017-07-21 02:57 |
| ISSN |
2219-2816 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Basic Study |
| Article Title |
Urinary supersaturation as a diagnostic measure in urolithiasis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Otakar Söhnel and Felix Grases |
| Funding Agency and Grant Number |
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| Corresponding Author |
Felix Grases, PhD, Professor, Director of the Laboratory of Renal Lithiasis Research, Director of the University Institute of Health Sciences Research, Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research, University of Balearic Islands, Carretera Valldemossa Km 7.5, 07122 Palma of Mallorca, Spain. fgrases@uib.es
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| Key Words |
Urinary supersaturation; Heterogeneous nucleation; Urolithiasis |
| Core Tip |
The supersaturation of urinary compounds has been considered during long time as a key risk factor for renal lithiasis. Nevertheless, theoretical studies demonstrate that the rate of spontaneous (homogeneous) nucleation of calcium oxalate monohydrate and brushite only occurs at urinary supersaturations much higher than conceivable in any individual. This demonstrates the necessity of presence of efficient substances or foreign solid particles for induced nucleation (heterogeneous) of lithiatic compounds. Consequently, urinary supersaturation per se is necessary but not sufficient condition for stone development. Fundamental condition of renal stone formation and development is presence of heteronuclei and significantly reduced content of crystal growth inhibitors. Identification of nucleation promoters and absence of crystal growth inhibitors is very important as a diagnostic aspect to avoid urolithiasis. |
| Publish Date |
2017-07-21 02:57 |
| Citation |
Söhnel O, Grases F. Urinary supersaturation as a diagnostic measure in urolithiasis. World J Clin Urol 2017; 6(2): 40-43 |
| URL |
http://www.wjgnet.com/2219-2816/full/6/i2/40.htm |
| DOI |
http://dx.doi.org/10.5410/wjcu.v6.i2.40 |
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