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2/22/2017 10:06:00 AM | Browse: 654 | Download: 1409
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Received |
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2016-11-15 14:53 |
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Peer-Review Started |
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2016-11-15 15:06 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-12-20 11:07 |
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Revised |
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2016-12-27 15:32 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2017-01-06 15:25 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-01-11 11:42 |
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Articles in Press |
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2017-01-11 11:42 |
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Edit the Manuscript by Language Editor |
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2017-01-16 21:40 |
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Typeset the Manuscript |
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2017-02-14 17:23 |
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Publish the Manuscript Online |
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2017-02-20 17:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ning Yang, Juan-Juan Shi, Feng-Ping Wu, Mei Li, Xin Zhang, Ya-Ping Li, Song Zhai, Xiao-Li Jia and Shuang-Suo Dang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Liver Fibrosis Foundation of Wang Bao-En of China |
20100033 |
| the Science and Technology Foundation of Shaanxi Province of China |
2010K01-199 |
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| Corresponding Author |
Shuang-Suo Dang, PhD, MD, Department of Infectious Diseases, the Second Affiliated Hospital of Medical School of Xi’an Jiaotong University, No. 157 Xi’wu Road, Xi’an 710004, Shaanxi Province,
China. dang212@126.com
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| Key Words |
Caffeic acid phenethyl ester; Liver fibrosis; Antioxidation; Nrf2; Mitogen activated protein kinases |
| Core Tip |
Liver fibrosis is a pathological response to hepatocyte injury, including oxidative stress, which is a primary mechanism of liver damage. Caffeic acid phenethyl ester (CAPE) is a phenolic compound extracted from honeybee propolis that has strong biological properties in liver protection and as an antioxidant and anti-fibrosis agent. It has been used in the treatment of several diseases. In this study, we investigated the antioxidant effect of CAPE in HSC-T6 cells and its potential mechanism. Our results demonstrated that CAPE inhibited cell proliferation and up-regulated the antioxidant levels in HSC-T6 cells partly through the Nrf2-MAPKs signaling pathway.
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| Publish Date |
2017-02-20 17:58 |
| Citation |
Yang N, Shi JJ, Wu FP, Li M, Zhang X, Li YP, Zhai S, Jia XL, Dang SS. Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway. World J Gastroenterol 2017; 23(7): 1203-1214 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i7/1203.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i7.1203 |
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