Publication Name	World Journal of Gastroenterology
Manuscript ID	31446
Country	United States

Received	2016-11-17 08:38
Peer-Review Started	2016-11-18 11:21
To Make the First Decision	2017-04-21 08:24
Return for Revision	2017-04-24 16:24
Revised	2017-06-05 06:55
Second Decision	2017-06-16 12:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-06-19 09:06
Articles in Press	2017-06-19 09:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-30 06:21
Publish the Manuscript Online	2017-07-12 06:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Fibrinogen deficiency suppresses the development of early and delayed radiation enteropathy
Manuscript Source	Invited Manuscript
All Author List	Junru Wang, Rupak Pathak, Sarita Garg and Martin Hauer-Jensen
Funding Agency and Grant Number
Corresponding Author	Martin Hauer-Jensen, MD, PhD, Director, Director, Professor, Division of Radiation Health, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, United States. mhjensen@uams.edu
Key Words	Radiation enteropathy; Knockout mouse model; Fibrinogen; Inflammation; Fibrosis; Ionizing radiation
Core Tip	Fibrinogen, a plasma protein, and fibrin (breakdown product of fibrinogen) induce inflammation, and fibrosis. Suppression of coagulation, inflammation, and fibrosis attenuate intestinal radiation injury. While fibrinogen has been presumed to be involved in intestinal fibrosis development, a direct role has only been supported by indirect evidence. We investigated the direct role of fibrinogen deficiency in early and delayed intestinal radiation injury. Radiation caused less intestinal injury in mice deficient in the fibrinogen gene, than in mice bearing two or one wild type fibrinogen alleles. We conclude that fibrinogen is essential for full-blown intestinal radiation fibrosis to occur.
Publish Date	2017-07-12 06:45
Citation	Wang J, Pathak R, Garg S, Hauer-Jensen M. Fibrinogen deficiency suppresses the development of early and delayed radiation enteropathy. World J Gastroenterol 2017; 23(26): 4701-4711
URL	http://www.wjgnet.com/1007-9327/full/v23/i26/4701.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i26.4701

Full Article (PDF)	WJG-23-4701.pdf
Full Article (Word)	WJG-23-4701.doc
Manuscript File	31446-Review.doc
Answering Reviewers	31446-Answering reviewers.pdf
Audio Core Tip	31446-Audio core tip.mp3
Biostatistics Review Certificate	31446-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31446-Conflict-of-interest statement.pdf
Copyright License Agreement	31446-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	31446-Institutional animal care and use committee statement.pdf
Peer-review Report	31446-Peer-review(s).pdf
Scientific Misconduct Check	31446-Scientific misconduct check.pdf
Scientific Editor Work List	31446-Scientific editor work list.pdf