Publication Name	World Journal of Gastroenterology
Manuscript ID	31752
Country	China

Received	2016-12-06 11:07
Peer-Review Started	2016-12-06 21:09
First Decision by Editorial Office Director
Return for Revision	2016-12-30 10:34
Revised	2017-01-13 10:36
Publication Fee Transferred
Second Decision by Editor	2017-02-15 21:10
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-02-17 13:11
Articles in Press	2017-02-17 13:11
Edit the Manuscript by Language Editor	2017-03-21 23:40
Typeset the Manuscript	2017-04-11 11:11
Publish the Manuscript Online	2017-04-20 15:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Urinary metabolomics analysis identifies key biomarkers of different stages of nonalcoholic fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Shu Dong, Zong-Ying Zhan, Hong-Yan Cao, Chao Wu, Yan-Qin Bian, Jian-Yuan Li, Gen-Hong Cheng, Ping Liu and Ming-Yu Sun
Funding Agency and Grant Number	Funding Agency Grant Number Major Project of Shanghai Municipal S&T Commission 15DZ1900104 National Natural Science Foundation 81273729
Corresponding Author	Ming-yu Sun, MD, PhD, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New District, Shanghai 201203, China. mysun248@hotmail.com
Key Words	Urinary metabonomics; Nonalcoholic fatty liver disease; Steatohepatitis
Core Tip	To identify biomarkers that can distinguish between nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), urine and blood were obtained from patients with NAFLD and NASH, and healthy controls. Urinary metabonomics found differences in 31 metabolites between NAFLD and NASH, including nucleic acids and amino acids. Pathway analysis showed that pathways of energy metabolism, amino acid metabolism, and the pentose phosphate pathway, were closely associated with the pathological processes in NAFLD and NASH. These biomarkers could distinguish between NAFLD and NASH, and could help to determine the mechanism involved in the development of NASH from NAFLD.
Publish Date	2017-04-20 15:58
Citation	Dong S, Zhan ZY, Cao HY, Wu C, Bian YQ, Li JY, Cheng GH, Liu P, Sun MY. Urinary metabolomics analysis identifies key biomarkers of different stages of nonalcoholic fatty liver disease. World J Gastroenterol 2017; 23(15): 2771-2784
URL	http://www.wjgnet.com/1007-9327/full/v23/i15/2771.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i15.2771

Full Article (PDF)	WJG-23-2771.pdf
Full Article (Word)	WJG-23-2771.doc
Manuscript File	31752-Review.docx
Answering Reviewers	31752-Answering reviewers.pdf
Audio Core Tip	31752-Audio core tip.wav
Biostatistics Review Certificate	31752-Biostatistics statement.pdf
Clinical Trial Registration Statement	31752-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	31752-Conflict-of-interest statement.pdf
Copyright License Agreement	31752-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20161205155817.docx
Institutional Animal Care and Use Committee Approval Form or Document	31752-Institutional animal care and use committee statement.docx
Institutional Review Board Approval Form or Document	31752-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	31752-Language certificate.pdf
Peer-review Report	31752-Peer-review(s).pdf
Scientific Misconduct Check	31372-Scientific misconduct check.pdf
Scientific Editor Work List	31752-Scientific editor work list.pdf