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Publication Name World Journal of Virology
Manuscript ID 32005
Country/Territory Portugal
Received
2016-12-21 09:43
Peer-Review Started
2016-12-25 11:52
To Make the First Decision
2017-01-14 11:28
Return for Revision
2017-01-16 19:29
Revised
2017-01-30 19:20
Second Decision
2017-02-20 16:02
Accepted by Journal Editor-in-Chief
2017-02-21 20:35
Accepted by Company Editor-in-Chief
2017-03-02 08:40
Articles in Press
2017-03-02 08:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-06 20:04
Publish the Manuscript Online
2017-05-12 22:16
ISSN 2220-3249 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Basic Study
Article Title Structural and nucleic acid binding properties of hepatitis delta virus small antigen
Manuscript Source Invited Manuscript
All Author List Carolina Alves, Hong Cheng, João Paulo Tavanez, Ana Casaca, Severin Gudima, Heinrich Roder and Celso Cunha
Funding Agency and Grant Number
Funding Agency Grant Number
Fundação para a Ciência e Tecnologia FCT, to GHTM - UID/Multi/04413/2013
FCT PhD grants
FCT post-doctoral fellowship SFRH/BPD/87494/2012
Corresponding Author Celso Cunha, Associate Professor, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Rua da Junqueira 100, 1349-008 Lisboa, Portugal. ccunha@ihmt.unl.pt
Key Words Hepatitis delta virus; Delta antigen; Nuclear magnetic resonance; Circular dichroism; Intrinsi­cally disordered protein
Core Tip The characterization of a truncated form of S-HDAg lacking amino acids 1-60, ?60HDAg is reported. Structure of ?60HDAg was assessed by circular dichroism and nuclear magnetic resonance and its nucleic acid binding properties were investigated using gel retardation assays. This study demonstrates for the first time that ?60HDAg is intrinsically disordered and a monomer. Furthermore, ?60HDAg can bind a wide variety of nucleic acids without apparent specificity.
Publish Date 2017-05-12 22:16
Citation Alves C, Cheng H, Tavanez JP, Casaca A, Gudima S, Roder H, Cunha C. Structural and nucleic acid binding properties of hepatitis delta virus small antigen. World J Virol 2017; 6(2): 26-35
URL http://www.wjgnet.com/2220-3249/full/v6/i2/26.htm
DOI http://dx.doi.org/10.5501/wjv.v6.i2.26
Full Article (PDF) WJV-6-26.pdf
Full Article (Word) WJV-6-26.doc
Manuscript File 32005-Review.docx
Answering Reviewers 32005-Answering reviewers.pdf
Audio Core Tip 32005-Audio core tip.WAV
Biostatistics Review Certificate 32005-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 32005-Conflict-of-interest statement.pdf
Copyright License Agreement 32005-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32005-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 32005-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 32005-Institutional review board statement.pdf
Peer-review Report 32005-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 32005-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 32005-Scientific misconduct check.pdf
Scientific Editor Work List 32005-Scientific editor work list.pdf