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9/7/2017 6:18:45 AM | Browse: 47 | Download: 56
Publication Name World Journal of Hepatology
Manuscript ID 32372
Country of Manuscript Source Argentina
Received
2017-01-05 09:56
Peer-Review Started
2017-01-07 08:41
To Make the First Decision
2017-04-17 15:53
Return for Revision
2017-04-20 15:28
Revised
2017-04-29 00:45
Second Decision
2017-05-17 09:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-24 01:03
Articles in Press
2017-05-24 01:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-25 08:04
Publish the Manuscript Online
2017-09-07 02:39
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients
Manuscript Source Invited Manuscript
All Author List Natalia Laufer, Diego Ojeda, María Laura Polo, Ana Martinez, Héctor Pérez, Gabriela Turk, Pedro Cahn, Norberto Walter Zwirner and Jorge Quarleri
Funding Agency and Grant Number
Correspondence To Natalia Laufer, MD, PhD, Investigador Asistente – CONICET, Instituto Investigaciones Biomédicas en Retrovirus y SIDA INBIRS, Universidad de Buenos Aires. Paraguay 2155 Piso 11, Buenos Aires C1121ABG, Argentina. nlaufer@fmed.uba.ar
Keywords CD4+ T cell; Human immunodeficiency virus/hepatitis C virus-coinfection; Fibrosis; Biomarker; Natural killer cells
Core Tip Approximately 2.3 million individuals with human immunodeficiency virus are coinfected with hepatitis C virus (HCV). The high cost of HCV treatment restricts its use. It is crucial to identify patients with advanced liver fibrosis with an urgent need of treatment. The aim of this study was to identify natural killer (NK) phenotypes as a biomarker for liver fibrosis. We observed that those subjects with higher fibrosis are those with lower percentage of NK cells and also with lower LTCD4+ count. These constitute two simple parameters that might be performed in a routine laboratory test and used in clinical practice as biomarkers for liver fibrosis.
Publish Date 2017-09-07 02:39
Citation Laufer N, Ojeda D, Polo ML, Martinez A, Pérez H, Turk G, Cahn P, Zwirner NW, Quarleri J. CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients. World J Hepatol 2017; 9(25): 1073-1080
Url http://www.wjgnet.com/1948-5182/full/v9/i25/1073.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i25.1073
Full Article (PDF) WJH-9-1073.pdf
Full Article (Word) WJH-9-1073.doc
Revised Manuscript 32372-Review.docx
Peer-review Report 32372-Peer-review(s).pdf
Answering Reviewers 32372-Answering reviewers.pdf
Scientific Misconduct Check 32372-Scientific misconduct check.pdf
Scientific Editor Work List 32372-Scientific editor work list.pdf
Audio 32372-Audio core tip.mp4
Biostatistics Statement 32372-Biostatistics statement.pdf
Conflict-of-Interest Statement 32372-Conflict-of-interest statement.pdf
Copyright Assignment 32372-Copyright assignment.pdf
Data Sharing Statement 32372-Data sharing statement.pdf
Informed Consent Statement 32372-Informed consent statement.pdf
Institutional Review Board Statement 32372-Institutional review board statement.pdf
Non-Native Speakers of English 32372-Language certificate.pdf
Scientific Research Process 32372-Scientific research process.pdf