Publication Name	World Journal of Gastroenterology
Manuscript ID	32393
Country	China

Received	2017-01-06 09:40
Peer-Review Started	2017-01-09 09:24
To Make the First Decision	2017-03-03 09:00
Return for Revision	2017-03-07 19:55
Revised	2017-03-20 16:32
Second Decision	2017-04-27 17:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-04 18:21
Articles in Press	2017-05-04 18:21
Publication Fee Transferred	2017-05-05 17:10
Edit the Manuscript by Language Editor	2017-05-09 19:17
Typeset the Manuscript	2017-06-09 09:32
Publish the Manuscript Online	2017-06-14 09:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Basic Study
Article Title	Effect of CXCR3/HO-1 genes modified bone marrow mesenchymal stem cells on small bowel transplant rejection
Manuscript Source	Unsolicited Manuscript
All Author List	Ming-Li Yin, Hong-Li Song, Yang Yang, Wei-Ping Zheng, Tao Liu and Zhong-Yang Shen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81270528 National Natural Science Foundation of China 81441022 National Natural Science Foundation of China 81670574 Natural Science Foundation of Tianjin, China 08JCYBJC08400 Natural Science Foundation of Tianjin, China 11JCZDJC27800 The Natural Science Foundation of Tianjin, China 12JCZDJC25200 Technology Foundation of the Health Bureau in Tianjin, China 2011KY11
Corresponding Author	Zhong-Yang Shen, MD, PhD, Professor, Department of Organ Transplantation, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin 300192, China. shenzhy@tmu.edu.cn
Key Words	bone marrow mesenchymal stem cells; CXCR3; HO-1; Small bowel transplantation; Rejection
Core Tip	In this paper, transplant recipient rats were pretreated with bone marrow mesenchymal stem cells (BMMSCs) in advance, and these rats were in a compromised immune state. CXCR3/HO-1 gene modified BMMSCs were injected into recipient rats after small bowel transplantation. The survival time of these rats was significantly prolonged; the number of cells that underwent apoptosis was significantly lower in the CXCR3/HO-1 modified BMMSCs group compared with rats from the HO-1 gene modified BMMSCs group, the native BMMSCs group, and the NS group. Furthermore, the percentage of regulatory T cells was significantly increased. Proinflammatory cytokines (IL-2, IL-6, IL-17, IFN-γ, and TNF-α) were significantly reduced, while anti-inflammatory cytokines (IL-10 and TGF-β) were significantly increased. Our data suggest that BMMSCs modified with the CXCR3 and HO-1 gene can reduce rejection of the small intestine more effectively than HO-1 modified BMMSCs and native BMMSCs.
Publish Date	2017-06-14 09:25
Citation	Yin ML, Song HL, Yang Y, Zheng WP, Liu T, Shen ZY. Effect of CXCR3/HO-1 genes modified bone marrow mesenchymal stem cells on small bowel transplant rejection. World J Gastroenterol 2017; 23(22): 4016-4038
URL	http://www.wjgnet.com/1007-9327/full/v23/i22/4016.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i22.4016

Full Article (PDF)	WJG-23-4016.pdf
Full Article (Word)	WJG-23-4016.doc
Manuscript File	32393-Review.doc
Answering Reviewers	32393-Answering reviewers.pdf
Audio Core Tip	32393-Audio core tip.mp3
Biostatistics Review Certificate	32393-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	32393-Conflict-of-interest statement.pdf
Copyright License Agreement	32393-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	32393-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	32393-Institutional review board statement.pdf
Institutional Review Board Approval Form or Document	32393-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	32393-Language certificate.pdf
Peer-review Report	32393-Peer-review(s).pdf
Scientific Misconduct Check	32393-Scientific misconduct check.pdf
Scientific Editor Work List	32393-Scientific editor work list.pdf