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6/14/2017 2:46:02 AM | Browse: 631 | Download: 1687
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Received |
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2017-01-30 15:54 |
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Peer-Review Started |
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2017-02-08 10:19 |
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To Make the First Decision |
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2017-03-08 09:34 |
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Return for Revision |
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2017-03-09 15:15 |
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Revised |
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2017-04-01 00:17 |
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Second Decision |
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2017-04-27 17:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-05-05 18:27 |
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Articles in Press |
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2017-05-05 18:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-16 01:40 |
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Publish the Manuscript Online |
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2017-05-22 01:34 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non- commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Role of LIGHT in the pathogenesis of joint destruction in rheumatoid arthritis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Afsie Sabokbar, Sara Afrough, David J Mahoney, Yoshinobu Uchihara, Catherine Swales and Nicholas A Athanasou |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Rosetrees Trust |
242 |
| Arthritis Research Campaign (UK) |
18358 |
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| Corresponding Author |
Nicholas A Athanasou, MD, PhD, FRC (Path), Professor of Musculoskeletal Pathology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Windmill Rd, Oxford, OX3 7HE, United Kingdom. nick.athanasou@ndorms.ox.ac.uk |
| Key Words |
Receptor-activator nuclear factor kappa-B ligand; Osteoclast; Rheumatoid arthritis; Resorption; LIGHT |
| Core Tip |
Rheumatoid arthritis (RA) is an inflammatory joint condition characterised by the formation of marginal erosions due to the activity of bone resorbing osteoclasts. Osteoclasts can be formed from macrophages by both receptor-activator nuclear factor kappa-B ligand (RANKL)-dependent and RANKL-independent mechanisms. LIGHT is a potent RANKL substitute that induces significant osteoclast formation from cultures of RA synovial fluid macrophages; this results in comparable levels of resorption to that seen in RANKL-treated cultures. LIGHT also stimulated RANKL-mediated lacunar resorption. LIGHT is highly expressed in RA joints and synovial fluid and is likely to play a key role in the pathogenesis of marginal erosion formation in RA. |
| Publish Date |
2017-05-22 01:34 |
| Citation |
Sabokbar A, Afrough S, Mahoney DJ, Uchihara Y, Swales C, Athanasou NA. Role of LIGHT in the pathogenesis of joint destruction in rheumatoid arthritis. World J Exp Med 2017; 7(2): 49-57 |
| URL |
http://www.wjgnet.com/2220-315X/full/v7/i2/49.htm |
| DOI |
http://dx.doi.org/10.5493/wjem.v7.i2.49 |
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