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9/27/2017 1:08:51 AM | Browse: 708 | Download: 1449
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Received |
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2017-02-03 16:03 |
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Peer-Review Started |
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2017-02-08 15:39 |
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To Make the First Decision |
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2017-03-27 12:07 |
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Return for Revision |
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2017-03-31 14:16 |
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Revised |
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2017-04-06 20:14 |
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Second Decision |
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2017-06-02 08:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-06-13 05:55 |
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Articles in Press |
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2017-06-13 05:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-09-21 01:40 |
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Publish the Manuscript Online |
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2017-09-26 09:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
T-cell allorecognition of donor glutathione S-transferase T1 in plasma cell-rich rejection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
María José Martínez-Bravo, Berta Sánchez, José Manuel Sousa, María José Acevedo, Miguel Angel Gómez-Bravo, Antonio Núñez-Roldán and Isabel Aguilera |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Spanish Ministry of Economy, Instituto de Salud Carlos III |
11/0857 |
| Andalusian goverment |
PI-0332-2007 |
| Spanish Ministry of Economy, Instituto de Salud Carlos III |
10/2332 |
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| Corresponding Author |
Isabel Aguilera, PhD, Immunology Service, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avda. Manuel Siurot s/n, 41013 Seville, Spain. iaguilera-ibis@us.es |
| Key Words |
Donor-specific glutathione S-transferase T1 antibodies; Indirect presentation; Glutathione S-transferase T1-memory T cells; De novo immune hepatitis; Donor/recipient mismatch |
| Core Tip |
In solid organ transplants, donor recipient mismatch of glutathione S-transferase T1 (GSTT1) alleles triggers a specific immune response with the production of IgG antibodies. In a proportion of mismatched liver and kidney transplants, the clinical outcome is rejection. However, detection of GSTT1-specific T lymphocytes has not been documented. We provide the first evidence of T cells able to become activated by GSTT1 peptides in patients who develop plasma cell-rich (PC-rich) rejection after GSTT1-mismatch liver transplantation. Interestingly, not only CD8+ or CD4+ cells but also double positive CD4+CD8low cells reacted to the antigenic stimulation in vitro. |
| Publish Date |
2017-09-26 09:09 |
| Citation |
Martínez-Bravo JM, Sánchez B, Sousa JM, Acevedo MJ, Gómez-Bravo MA, Núñez-Roldán A, Aguilera I. T-cell allorecognition of donor glutathione S-transferase T1 in plasma cell-rich rejection. World J Hepatol 2017; 9(27): 1115-1124 |
| URL |
http://www.wjgnet.com/1948-5182/full/v9/i27/1115.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v9.i27.1115 |
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