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8/10/2017 7:58:48 AM | Browse: 914 | Download: 1884
Publication Name World Journal of Virology
Manuscript ID 33083
Country/Territory United States
Received
2017-02-06 16:56
Peer-Review Started
2017-02-07 10:35
To Make the First Decision
2017-03-08 09:41
Return for Revision
2017-03-10 17:07
Revised
2017-04-28 02:43
Second Decision
2017-05-24 01:05
Accepted by Journal Editor-in-Chief
2017-05-25 06:16
Accepted by Company Editor-in-Chief
2017-06-07 07:21
Articles in Press
2017-06-07 07:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-08 09:17
Publish the Manuscript Online
2017-08-09 04:13
ISSN 2220-3249 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Basic Study
Article Title Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes
Manuscript Source Invited Manuscript
All Author List Eyone Jones, Pavel Mazirka, Margaret A McNurlan, Frank Darras, Marie C Gelato and Giuseppe Caso
Funding Agency and Grant Number
Corresponding Author Giuseppe Caso, MD, PhD, Department of Surgery, Stony Brook University Medical Center, 100 Nicolls Rd, Stony Brook, NY 11794, United States. giuseppe.caso@stonybrook.edu
Key Words Nucleoside reverse transcriptase inhibitors; Non-nucleoside reverse transcriptase inhibitors; Protease inhibitors; Pre-adipocytes; Highly active antiretroviral therapy; Lipodystrophy
Core Tip We demonstrated an in vitro system for evaluating potential antiretroviral regimens for adipose tissue toxicity. In general, combination regimens resulted in greater preadipocyte proliferation and differentiation inhibition than single therapies. The drug combination of atazanavir + emtricitabine + tenofovir had inhibitory effects on preadipocytes and adding ritonavir at levels equivalent to clinical boosting, increased toxicity still further.
Publish Date 2017-08-09 04:13
Citation Jones E, Mazirka P, McNurlan MA, Darras F, Gelato MC, Caso G. Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes. World J Virol 2017; 6(3): 53-58
URL http://www.wjgnet.com/2220-3249/full/v6/i3/53.htm
DOI http://dx.doi.org/10.5501/wjv.v6.i3.53
Full Article (PDF) WJV-6-53.pdf
Full Article (Word) WJV-6-53.doc
Manuscript File 33083-Review.docx
Answering Reviewers 33083-Answering reviewers.pdf
Audio Core Tip 33083-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 33083-Conflict-of-interest statement.pdf
Copyright License Agreement 33083-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20170128013940.docx
Institutional Review Board Approval Form or Document 33083-Institutional review board statement.pdf
Peer-review Report 33083-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 33083-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 33083-Scientific misconduct check.pdf
Scientific Editor Work List 33083-Scientific editor work list.pdf