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9/26/2017 12:30:20 AM | Browse: 770 | Download: 847
Publication Name World Journal of Gastroenterology
Manuscript ID 33322
Country/Territory Italy
Received
2017-02-07 10:23
Peer-Review Started
2017-02-08 12:57
To Make the First Decision
2017-03-16 11:34
Return for Revision
2017-03-17 15:48
Revised
2017-04-15 23:02
Second Decision
2017-06-27 00:38
Accepted by Journal Editor-in-Chief
2017-06-27 06:44
Accepted by Company Editor-in-Chief
2017-07-04 06:08
Articles in Press
2017-07-04 06:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-11 02:55
Publish the Manuscript Online
2017-09-25 08:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond
Manuscript Source Invited Manuscript
All Author List Emanuele Sinagra, Gaetano Cristian Morreale, Ghazaleh Mohammadian, Giorgio Fusco, Valentina Guarnotta, Giovanni Tomasello, Francesco Cappello, Francesca Rossi, Georgios Amvrosiadis and Dario Raimondo
Funding Agency and Grant Number
Corresponding Author Emanuele Sinagra, Doctor, Gastroenterology and Endoscopy Unit, Fondazione Istituto Giuseppe Giglio, Contrada Pietra Pollastra Pisciotto, Cefalù 90015, Italy. emanuelesinagra83@googlemail.com
Key Words Therapy; Low grade inflammation; Motility; Secretion; Irritable bowel syndrome; Immunoendocrine axis
Core Tip Irritable bowel syndrome (IBS) is a chronic, recurring, and remitting functional disorder of the gastrointestinal tract characterized by abdominal pain, distention, and changes in bowel habits. Despite there are several drugs for IBS, effective and approved treatments for one or more of the symptoms for various IBS subtypes are needed. The understanding of pathophysiological mechanisms such as the role of impaired bile acid metabolism, neurohormonal regulation, immune dysfunction, the epithelial barrier and secretory properties of the gut has led to advancements in the treatment of IBS. This literature review aims to summarize the findings relating the new and investi­gational therapeutic agents for IBS, most recently developed in preclinical as well as Phase 1 and Phase 2 clinical studies.
Publish Date 2017-09-25 08:56
Citation Sinagra E, Morreale GC, Mohammadian G, Fusco G, Guarnotta V, Tomasello G, Cappello F, Rossi F, Amvrosiadis G, Raimondo D. New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond. World J Gastroenterol 2017; 23(36): 6593-6627
URL http://www.wjgnet.com/1007-9327/full/v23/i36/6593.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i36.6593
Full Article (PDF) WJG-23-6593.pdf
Full Article (Word) WJG-23-6593.doc
Manuscript File 33322-Review.doc
Answering Reviewers 33322-Answering reviewers.pdf
Audio Core Tip 33322-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 33322-Conflict-of-interest statement.pdf
Copyright License Agreement 33322-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 33322-Language certificate.pdf
Peer-review Report 33322-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 33322-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 33322-Scientific misconduct check.pdf
Scientific Editor Work List 33322-Scientific editor work list.pdf