Publication Name	World Journal of Gastroenterology
Manuscript ID	33478
Country	Argentina

Received	2017-02-13 14:35
Peer-Review Started	2017-02-14 16:45
To Make the First Decision	2017-04-21 08:33
Return for Revision	2017-04-24 16:22
Revised	2017-05-04 22:07
Second Decision	2017-06-12 05:55
Accepted by Journal Editor-in-Chief	2017-06-12 09:21
Accepted by Executive Editor-in-Chief	2017-06-19 09:09
Articles in Press	2017-06-19 09:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-25 11:09
Publish the Manuscript Online	2017-08-07 09:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression
Manuscript Source	Invited Manuscript
All Author List	María L Bacigalupo, Pablo Carabias and María F Troncoso
Funding Agency and Grant Number	Funding Agency Grant Number CONICET (PIP-647) and UBA (Programación Científica 2016-2019, No. 20020150100005BA) to Troncoso MF
Corresponding Author	María F Troncoso, PhD, Facultad de Farmacia y Bioquímica, Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Consejo Nacional de lnvesti­gaciones Científicas y Técnicas, Universidad de Buenos Aires, Junín 956, Buenos Aires C1113AAD, Argentina. fernanda@qb.ffyb.uba.ar
Key Words	Galectin-1; Gastric cancer; Hepatocellular carcinoma; Colorectal carcinoma; Pancreatic cancer; β1,6-N-acetylglucosaminyltransferase V
Core Tip	Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. Galectin-1 (Gal-1) is a β-galactoside-binding protein with the ability to cross-link specific glycoconjugates. Accumulating evidence shows that Gal-1 in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues is up-regulated. Moreover, high levels of this galectin correlate with tumor development, aggressiveness, metastasis, immunosupression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression.
Publish Date	2017-08-07 09:17
Citation	Bacigalupo ML, Carabias P, Troncoso MF. Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression. World J Gastroenterol 2017; 23(29): 5266-5281
URL	http://www.wjgnet.com/1007-9327/full/v23/i29/5266.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i29.5266

Full Article (PDF)	WJG-23-5266.pdf
Full Article (Word)	WJG-23-5266.doc
Manuscript File	33478-Review.docx
Answering Reviewers	33478-Answering reviewers.pdf
Audio Core Tip	33478-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33478-Conflict-of-interest statement.pdf
Copyright License Agreement	33478-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	33478-Grant application form(s).pdf
Peer-review Report	33478-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33478-Journal editor-in-chief review report.pdf
Scientific Editor Work List	33478-Scientific editor work list.pdf