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8/7/2017 7:29:06 AM | Browse: 342 | Download: 296
Publication Name World Journal of Hematology
Manuscript ID 34006
Country of Manuscript Source Netherlands
Received
2017-03-20 13:03
Peer-Review Started
2017-03-24 08:27
To Make the First Decision
2017-04-14 08:13
Return for Revision
2017-04-18 13:58
Revised
2017-04-27 08:45
Second Decision
2017-07-06 09:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-07-17 06:13
Articles in Press
2017-07-17 06:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-04 03:02
Publish the Manuscript Online
2017-08-07 04:59
ISSN 2218-6204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Hematology
Manuscript type Review
Article Title Aspirin cures erythromelalgia and cerebrovascular disturbances in JAK2-thrombocythemia through platelet-cycloxygenase inhibition
Manuscript Source Invited Manuscript
All Author List Jan Jacques Michiels
Funding Agency and Grant Number
Correspondence To Jan Jacques Michiels, MD, PhD, Doctor, Professor, Goodheart Insitute Freedom of Science and Education in Nature Medicine and Health, Erasmus Tower, Veenmos 13, Rotterdam 3969 AT, Netherlands. goodheartcenter@upcmail.nl
Keywords Aspirin; Wonder drug; Erythromelalgia; Cerebral vascular disturbances; Platelet cyclooxygenase; Migraine
Core Tip About seventy years after the synthesis by Hoffmann, acetyl salicylic acid (aspirin) has been discovered in the late 1970s as a wunder drug that cures erythromelalgia and migraine-like cerebral microvascular disturbances by irreversible blockage of platelet cyclo-oxygenase mediated arteriolar inflammation and thrombosis in JAK2-mutated thrombocythemia of patients with essential thrombocythemia (ET) and polycythemia vera (PV). The ADP (P2Y12) receptor inhibtors ticlopedin and clopidogrel, other platelet inhibitors that do not affect platelet cycooxygenase, and coumarin are ineffective in the treatment of erythromelalgia and cerebral vascular thrombotic complications in ET and PV.
Publish Date 2017-08-07 04:59
Citation Michiels JJ. Aspirin cures erythromelalgia and cerebrovascular disturbances in JAK2-thrombocythemia through platelet-cycloxygenase inhibition. World J Hematol 2017; 6(3): 32-54
Url http://www.wjgnet.com/2218-6204/full/v6/i3/32.htm
DOI http://dx.doi.org/10.5315/wjh.v6.i3.32
Full Article (PDF) WJH-6-32.pdf
Full Article (Word) WJH-6-32.doc
Manuscript File 34006-Review.docx
Answering Reviewers 34006-Answering reviewers.pdf
Audio Core Tip 34006-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 34006-Conflict-of-interest statement.pdf
Copyright License Agreement 34006-Copyright assignment.pdf
Peer-review Report 34006-Peer-review(s).pdf
Scientific Misconduct Check 34006-Scientific misconduct check.pdf
Scientific Editor Work List 34006-Scientific editor work list.pdf