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8/28/2017 9:09:07 AM | Browse: 183 | Download: 479
Publication Name World Journal of Gastroenterology
Manuscript ID 34313
Country of Manuscript Source Greece
2017-04-13 08:43
Peer-Review Started
2017-04-14 07:58
To Make the First Decision
2017-06-05 00:57
Return for Revision
2017-06-07 00:14
2017-06-22 16:36
Second Decision
2017-07-21 08:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-07-24 02:29
Articles in Press
2017-07-24 02:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-08-01 22:36
Typeset the Manuscript
2017-08-16 06:46
Publish the Manuscript Online
2017-08-28 06:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer
Manuscript Source Invited Manuscript
All Author List Anastasios Ntavatzikos, Aris Spathis, Paul Patapis, Nikolaos Machairas, George Peros, Stefanos Konstantoudakis, Danai Leventakou, Ioannis G Panayiotides, Petros Karakitsos and Anna Koumarianou
Funding Agency and Grant Number
Funding Agency Grant Number
Kapodistrias, National and Kapodistrian University of Athens 70/3/8006
Kapodistrias, National and Kapodistrian University of Athens 70/3/9114
Spathis A was supported during data collection 70/3/8462
Correspondence To Anastasios Ntavatzikos, MD, Research Scientist, Surgeon, Hematology-Oncology Unit, 4th Department of Internal Medicine, Attikon University Hospital, Rimini 1, Haidari 12462, Athens, Greece. dmaal2@yahoo.gr
Keywords Thymidylate synthase; Polymorphisms; mCRC; Loss of heterozygosity; Survival; Chemotherapy; KRAS; BRAF; TYMS
Core Tip The etiology of resistance to new targeted agents and chemotherapy is currently being investi­gated based upon the patients’ genetic profile in order to develop a prognostic model that could lead to individualized treatment. In this context, we studied the effect of thymidylate synthase (TYMS) polymorphisms that have been described so far, taking into account the presence of KRAS and BRAF mutations in association with the treatment. TYMS 3’ untranslated region polymorphism ins/ins and ins/loss of heterozygosity emerged as an independent factor that increases the risk of both disease progression and death. Regimens that included irinotecan had reduced risk of disease progression and death.
Publish Date 2017-08-28 06:54
Citation Ntavatzikos A, Spathis A, Patapis P, Machairas Ν, Peros G, Konstantoudakis S, Leventakou D, Panayiotides IG, Karakitsos P, Koumarianou A. Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer. World J Gastroenterol 2017; 23(32): 5913-5924
Url http://www.wjgnet.com/1007-9327/full/v23/i32/5913.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i32.5913
Full Article (PDF) WJG-23-5913.pdf
Full Article (Word) WJG-23-5913.doc
Revised Manuscript 34313-Review.docx
Peer-review Report 34313-Peer-review(s).pdf
Answering Reviewers 34313-Answering reviewers.pdf
Scientific Misconduct Check 34313-Scientific misconduct check.pdf
Scientific Editor Work List 34313-Scientific editor work list.pdf
Audio Core Tip 34313-Audio core tip.mp3
Biostatistics Review Certificate 34313-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 34313-Conflict-of-interest statement.pdf
Copyright License Agreement 34313-Copyright assignment.pdf
Data Sharing Statement 34313-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) 34313-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 34313-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 34313-Language certificate.pdf
Scientific Research Process 34313-Scientific research process.pdf
Supplementary Material 34313-Supplementary material.docx