Category |
Gastroenterology & Hepatology |
Manuscript Type |
Retrospective Study |
Article Title |
Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer
|
Manuscript Source |
Invited Manuscript |
All Author List |
Anastasios Ntavatzikos, Aris Spathis, Paul Patapis, Nikolaos Machairas, George Peros, Stefanos Konstantoudakis, Danai Leventakou, Ioannis G Panayiotides, Petros Karakitsos and Anna Koumarianou |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Kapodistrias, National and Kapodistrian University of Athens |
70/3/8006 |
Kapodistrias, National and Kapodistrian University of Athens |
70/3/9114 |
Spathis A was supported during data collection |
70/3/8462 |
|
Corresponding Author |
Anastasios Ntavatzikos, MD, Research Scientist, Surgeon, Hematology-Oncology Unit, 4th Department of Internal Medicine, Attikon University Hospital, Rimini 1, Haidari 12462, Athens, Greece. dmaal2@yahoo.gr |
Key Words |
Thymidylate synthase; Polymorphisms; mCRC; Loss of heterozygosity; Survival; Chemotherapy; KRAS; BRAF; TYMS |
Core Tip |
The etiology of resistance to new targeted agents and chemotherapy is currently being investigated based upon the patients’ genetic profile in order to develop a prognostic model that could lead to individualized treatment. In this context, we studied the effect of thymidylate synthase (TYMS) polymorphisms that have been described so far, taking into account the presence of KRAS and BRAF mutations in association with the treatment. TYMS 3’ untranslated region polymorphism ins/ins and ins/loss of heterozygosity emerged as an independent factor that increases the risk of both disease progression and death. Regimens that included irinotecan had reduced risk of disease progression and death. |
Publish Date |
2017-08-28 06:54 |
Citation |
Ntavatzikos A, Spathis A, Patapis P, Machairas Ν, Peros G, Konstantoudakis S, Leventakou D, Panayiotides IG, Karakitsos P, Koumarianou A. Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer. World J Gastroenterol 2017; 23(32): 5913-5924 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i32/5913.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i32.5913 |