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12/5/2017 6:12:29 AM | Browse: 840 | Download: 923
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Received |
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2017-05-31 02:06 |
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Peer-Review Started |
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2017-06-01 09:51 |
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To Make the First Decision |
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2017-07-10 00:49 |
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Return for Revision |
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2017-07-20 02:53 |
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Revised |
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2017-08-10 14:43 |
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Second Decision |
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2017-09-14 07:08 |
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Accepted by Journal Editor-in-Chief |
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2017-09-14 09:05 |
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Accepted by Company Editor-in-Chief |
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2017-10-16 06:24 |
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Articles in Press |
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2017-10-16 06:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-11-28 04:21 |
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Publish the Manuscript Online |
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2017-12-05 01:55 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http:///creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Authors 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rim Jawad, Melroy D'souza, Lisa Arodin Selenius, Marita Wallenberg Lundgren, Olof Danielsson, Greg Nowak, Mikael Björnstedt and Bengt Isaksson |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Cancerfonden |
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| Cancer och Allergifonden |
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| Radiumhemmets forskningsfonder |
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| ALF |
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| Jochnick foundation |
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| Corresponding Author |
Melroy D'souza, Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141-86, Sweden. melroy.dsouza@karolinska.se |
| Key Words |
Hepatic ischemia-reperfusion injury; Ischemia reperfusion injury; Warm ischemia-reperfusion injury; Glutaredoxins; Thioredoxins; Electron microscopy; Oxidative stress; Portal triad clamping |
| Core Tip |
The complex mechanisms of warm Ischemia reperfusion (I/R) injury in the liver are diverse and have been widely studied but poorly understood. This study aims to investigate the ultrastructural changes at warm I/R injury induced by portal triad clamping. The effects were mainly borne by the liver sinusoidal endothelial cells (LSEC) which detached from the sinusoidal wall after ischemia. Interestingly we found that the LSECs reattached after reperfusion. Hepatocytes were unaffected except for the appearance of crystalline inclusions in the mitochondria. Investigation of redox related proteins showed no changes within our time frame. |
| Publish Date |
2017-12-05 01:55 |
| Citation |
Jawad R, D’souza M, Selenius LA, Lundgren MW, Danielsson O, Nowak G, Björnstedt M, Isaksson B. Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury. World J Hepatol 2017; 9(34): 1261-1269 |
| URL |
http://www.wjgnet.com/1948-5182/full/v9/i34/1261.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v9.i34.1261 |
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