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11/14/2017 11:53:32 AM | Browse: 708 | Download: 726
Publication Name World Journal of Gastroenterology
Manuscript ID 34724
Country/Territory Poland
Received
2017-05-23 01:07
Peer-Review Started
2017-05-23 14:52
To Make the First Decision
2017-06-22 01:02
Return for Revision
2017-06-23 09:12
Revised
2017-07-31 14:21
Second Decision
2017-08-09 01:38
Accepted by Journal Editor-in-Chief
2017-08-09 08:17
Accepted by Company Editor-in-Chief
2017-08-15 15:15
Articles in Press
2017-08-15 15:15
Publication Fee Transferred
2017-10-12 03:28
Edit the Manuscript by Language Editor
2017-10-25 15:41
Typeset the Manuscript
2017-11-06 04:39
Publish the Manuscript Online
2017-11-12 06:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Intestinal epithelium, intraepithelial lymphocytes, and the gut microbiota – Key players in the pathogenesis of celiac disease
Manuscript Source Unsolicited Manuscript
All Author List Bożena Cukrowska, Agnieszka Sowińska, Joanna Beata Bierła, Elżbieta Czarnowska, Anna Rybak and Urszula Grzybowska-Chlebowczyk
Funding Agency and Grant Number
Funding Agency Grant Number
The Children's Memorial Health Institute 236/15
The Children’s Memorial Health Institute 243/16
The Children’s Memorial Health Institute S147/2016
Corresponding Author Bożena Cukrowska, MD, PhD, Professor, Department of Pathology, Laboratory of Immunology, The Children’s Memorial Health Institute, Aleja Dzieci Polskich 20, Warsaw 04-730, Poland. b.cukrowska@ipczd.pl
Key Words Celiac disease; Intestinal microbiota; Epithelium; Intraepithelial lymphocytes; Intestinal barrier
Core Tip There is evidence that the host-microbiota homeostasis is disrupted in Celiac disease (CD) patients. Dysbiosis, meaning an imbalance in the gut microbiota and its metabolome, may activate innate immunity leading to pro-inflammatory changes, which induces intraepithelial lymphocyte infiltration and epithelial barrier damage, ultimately resulting in increased transfer of gluten peptides and inflammatory activation leading to CD development. The intestinal microbiota also has a direct effect on the breakdown of gluten and formation of immunogenic peptides. As colonization of the gut with microorganisms may be dependent on genetic factors, future prophylactic strategies may focus on gut microbiota modulation in genetically predisposed infants.
Publish Date 2017-11-12 06:39
Citation Cukrowska B, Sowińska A, Bierła JB, Czarnowska E, Rybak A, Grzybowska-Chlebowczyk U. Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota - Key players in the pathogenesis of celiac disease. World J Gastroenterol 2017; 23(42): 7505-7518
URL http://www.wjgnet.com/1007-9327/full/v23/i42/7505.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i42.7505
Full Article (PDF) WJG-23-7505.pdf
Full Article (Word) WJG-23-7505.doc
Manuscript File 34724-Review.doc
Answering Reviewers 34724-Answering-Reviewers-revision.docx
Audio Core Tip 34724-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 34724-Conflict-of-interest statement.pdf
Copyright License Agreement 34724-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34724-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 34724-Language certificate.pdf
Peer-review Report 34724-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 34724-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 34724-Scientific misconduct check.pdf
Scientific Editor Work List 34724-Scientific editor work list.pdf