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10/31/2017 12:13:49 AM | Browse: 875 | Download: 1425
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Received |
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2017-06-08 01:29 |
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Peer-Review Started |
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2017-06-08 07:48 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2017-08-14 13:44 |
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Revised |
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2017-09-19 14:36 |
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Publication Fee Transferred |
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2017-10-16 13:41 |
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Second Decision by Editor |
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2017-09-25 06:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-09-26 01:51 |
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Articles in Press |
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2017-09-26 01:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-10-23 03:22 |
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Publish the Manuscript Online |
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2017-10-29 06:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Physiology |
| Manuscript Type |
Basic Study |
| Article Title |
Glucagon-like peptide-2 modulates the nitrergic neurotransmission in strips from the mouse gastric fundus
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rachele Garella, Eglantina Idrizaj, Chiara Traini, Roberta Squecco, Maria Giuliana Vannucchi and Maria Caterina Baccari |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Florence (ex 60%) RICATEN14-16 to Baccari MC |
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| Corresponding Author |
Maria Caterina Baccari, PhD, Associate Professor, Department of Experimental and Clinical Medicine, Section of Physiology, University of Florence, Viale G.B. Morgagni 63, Florence 50134, Italy. mcaterina.baccari@unifi.it |
| Key Words |
Immunohistochemistry; Gastric motility; Glucagon-like peptide-2; Neuronal nitric oxide synthase; Non-adrenergic non-cholinergic neurotransmission |
| Core Tip |
The results of the present study demonstrate for the first time that, in strips from the mouse gastric fundus, glucagon-like peptide-2 (GLP-2) depresses the amplitude of the neurally-induced contractile responses and enhances the amplitude of the relaxant ones through the modulation of the nitrergic neurotransmission. GLP-2 also increases neuronal nitric oxide synthase immunoreactivity in the nerve structures. All these inhibitory effects might contribute to gastric relaxation, thus increasing the organ capacity. Since gastric distension represents a peripheral satiety signal from a physiological point of view, it could be speculated that the relaxant effects of GLP-2 might concur to suppress feeding behavior in rodents. |
| Publish Date |
2017-10-29 06:01 |
| Citation |
Garella R, Idrizaj E, Traini C, Squecco R, Vannucchi MG, Baccari MC. Glucagon-like peptide-2 modulates the nitrergic neurotransmission in strips from the mouse gastric fundus. World J Gastroenterol 2017; 23(40): 7211-7220 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i40/7211.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i40.7211 |
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