Publication Name	World Journal of Hepatology
Manuscript ID	35300
Country	Brazil

Received	2017-07-14 01:21
Peer-Review Started	2017-07-17 08:59
To Make the First Decision	2017-08-07 00:42
Return for Revision	2017-08-07 08:02
Revised	2017-08-21 15:40
Second Decision	2017-09-06 08:25
Accepted by Journal Editor-in-Chief	2017-09-06 14:09
Accepted by Company Editor-in-Chief	2017-11-03 22:32
Articles in Press	2017-11-03 22:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-06 07:06
Publish the Manuscript Online	2017-12-07 09:12

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis
Manuscript Source	Invited Manuscript
All Author List	Suelen A S Miozzo, Jorge A John, Marcelo C Appel-da-Silva, Isabella A Dossin, Cristiane V Tovo and Angelo A Mattos
Funding Agency and Grant Number
Corresponding Author	Cristiane V Tovo, MD, PhD, Adjunct Professor, Assistant Professor, Graduate Program in Medicine, Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Cel Aurelio Bitencourt 115/201, Porto Alegre CEP 90430-080, Brazil. cristianev@ufcspa.edu.br
Key Words	Cirrhosis; Bacterial infection; Spontaneous bacterial peritonitis; Proton pump inhibitors; Ascites
Core Tip	The aim of the present study was to inves¬tigate whether the use of proton pump inhibitors (PPIs) increases the incidence of spontaneous bacterial peritonitis (SBP) in patients with cirrhosis and ascites. An historical cohort study was carried out with cirrhotic patients. The primary outcome was development of SBP. Of 258 patients with ascites, 151 used PPIs, and 34 developed SBP (22.5%). Among 107 non-users of PPIs, 23 developed SBP (21.5%) (HR = 1.44, 95%CI: 0.85-2.47, P = 0.176). In conclusion, the use of PPIs does not increase the incidence of SBP in patients with cirrhosis and ascites.
Publish Date	2017-12-07 09:12
Citation	Miozzo SAS, John JA, Appel-da-Silva MC, Dossin IA, Tovo CV, Mattos AA. Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis. World J Hepatol 2017; 9(35): 1278-1285
URL	http://www.wjgnet.com/1948-5182/full/v9/i35/1278.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i35.1278

Full Article (PDF)	WJH-9-1278.pdf
Full Article (Word)	WJH-9-1278.doc
Manuscript File	35300-Review.docx
Answering Reviewers	35300-Answering reviewers.pdf
Audio Core Tip	35300-Audio core tip.mp3
Biostatistics Review Certificate	35300-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	35300-Conflict-of-interest statement.pdf
Copyright License Agreement	35300-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	35300-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s).pdf
Signed Informed Consent Form(s) or Document(s)	35300-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	35300-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	35300-Language certificate.pdf
Peer-review Report	35300-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	35300-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	35300-Scientific misconduct check.pdf
Scientific Editor Work List	35300-Scientific editor work list.pdf