Publication Name	World Journal of Clinical Oncology
Manuscript ID	37263
Country	Italy

Received	2017-11-25 09:09
Peer-Review Started	2017-11-25 16:09
To Make the First Decision	2018-01-15 03:27
Return for Revision	2018-01-15 08:18
Revised	2018-02-02 12:38
Second Decision	2018-02-08 11:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-03-15 01:44
Articles in Press	2018-03-15 01:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-03-27 14:06
Publish the Manuscript Online	2018-04-11 01:34

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/bync/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Cell-free DNA integrity for the monitoring of breast cancer:Future perspectives?
Manuscript Source	Invited Manuscript
All Author List	Navid Sobhani, Daniele Generali, Fabrizio Zanconati, Marina Bortul and Bruna Scaggiante
Funding Agency and Grant Number	Funding Agency Grant Number Ricerca Sanitaria 2015 LILT BEN2016/16
Corresponding Author	Bruna Scaggiante, PhD, Professor, Departement of Life Sciences, University of Trieste, Giorgeri 1, Trieste 34127, Italy. bscaggiante@units.it
Key Words	cfDNA integrity; Liquid biopsy; Breast cancer; ALU sequences; LINE-1 sequences
Core Tip	Despite the potentiality of cell-free DNA integrity as a useful tool for the monitoring of Breast Cancer (BC), evinced in some clinical studies, the scientific community has not reached agreeable conclusions to translate the results from the benchto-the-bedside yet. The main controversy regards the targets’ choice and the size of circulating cell-free tumor DNA fragments. This work underlines the utility of cell-free DNA Integrity evaluation for BC follow-up and at the same time highlights the common concepts explaining the different results in line of future directions.
Publish Date	2018-04-11 01:34
Citation	Sobhani N, Generali D, Zanconati F, Bortul M, Scaggiante B.Cell-free DNA integrity for the monitoring of breast cancer:Future perspectives? World J Clin Oncol 2018; 9(2): 26-32
URL	http://www.wjgnet.com/2218-4333/full/v9/i2/26.htm
DOI	http://dx.doi.org/10.5306/wjco.v9.i2.26

Full Article (PDF)	WJCO-9-26.pdf
Full Article (Word)	WJCO-9-26.doc
Manuscript File	37263-Review.docx
Answering Reviewers	37263-Answering reviewers.pdf
Audio Core Tip	37263-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	37263-Conflict-of-interest statement.pdf
Copyright License Agreement	37263-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	37263-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	37263-Language certificate.pdf
Peer-review Report	37263-Peer-review(s).pdf
Scientific Misconduct Check	37263-Scientific misconduct check.pdf
Scientific Editor Work List	37263-Scientific editor work list.pdf