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2/9/2018 1:54:17 AM | Browse: 1202 | Download: 987
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Received |
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2017-12-05 19:10 |
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Peer-Review Started |
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2017-12-06 08:47 |
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To Make the First Decision |
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2017-12-20 07:39 |
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Return for Revision |
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2017-12-21 12:18 |
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Revised |
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2018-01-05 19:34 |
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Second Decision |
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2018-01-19 09:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-01-19 18:41 |
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Articles in Press |
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2018-01-19 18:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-01-31 10:08 |
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Publish the Manuscript Online |
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2018-02-06 03:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Authors 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
High prevalence of hepatitis B-antibody loss and a case report of de novo hepatitis B virus infection in a child after living-donor liver transplantation
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| Manuscript Source |
Invited Conference Manuscripts |
| All Author List |
Palittiya Sintusek, Nawarat Posuwan, Piyaporn Wanawongsawad, Suttiruk Jitraruch, Yong Poovorawan and Voranush Chongsrisawat |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grants for development of New Faculty Staff, Ratchadaphiseksomphot Endowment Fund |
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| The Special Task Force for Activating Research in Immune Response in Children with Chronic Liver Diseases and Children after Liver Transplantation |
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| Research Chair Grant from the National Science and Technology Development Agency |
P-15-50004 |
| The Center of Excellence in Clinical Virology, Chulalongkorn Unversity and King Chulalongkorn Memorial Hospital |
GCE 5900930-005 |
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| Corresponding Author |
Voranush Chongsrisawat, MD, Lecturer, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, 1873, Rama 4 Road, Pathumwan, Bangkok 10330, Thailand. voranush.c@chula.ac.th |
| Key Words |
Hepatitis B vaccine; Liver transplantation; De novo hepatitis B infection; Anti-HBs antibody; Immunity |
| Core Tip |
Despite the completion of hepatitis B vaccination (HBV), loss of hepatitis B immunity in children after liver transplantation is common and we encountered a case of de novo HBV infection following liver transplantation. Serum anti-HBs, albumin, total bilirubin, and direct bilirubin prior to liver transplantation were identified as potential factors related to HBV immunity loss after liver transplantation. A booster dose of hepatitis B vaccine and raising serum albumin to normal levels could delay the rapid loss of HBV immunity after liver transplantation but may not prevent de novo hepatitis B. Consequently, strategies are required to maintain anti-HBs antibody above the protective level after liver transplantation. Regular assessment of anti-HBs after liver transplantation should also be considered along with revaccination to guarantee long-term protection from HBV infection. |
| Publish Date |
2018-02-06 03:22 |
| Citation |
Sintusek P, Posuwan N, Wanawongsawad P, Jitraruch S, Poovorawan Y, Chongsrisawat V. High prevalence of hepatitis B-antibody loss and a case report of de novo hepatitis B virus infection in a child after living-donor liver transplantation. World J Gastroenterol 2018; 24(6): 752-762 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i6/752.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i6.752 |
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