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9/14/2018 6:02:01 AM | Browse: 649 | Download: 870
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Received |
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2018-05-07 01:01 |
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Peer-Review Started |
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2018-05-07 03:20 |
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To Make the First Decision |
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2018-05-23 06:14 |
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Return for Revision |
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2018-05-25 11:10 |
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Revised |
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2018-06-16 06:51 |
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Second Decision |
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2018-06-26 11:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-06-27 04:10 |
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Articles in Press |
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2018-06-27 04:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-07-19 18:30 |
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Typeset the Manuscript |
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2018-09-03 08:11 |
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Publish the Manuscript Online |
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2018-09-14 05:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Formin-like 3 regulates RhoC/FAK pathway and actin assembly to promote cell invasion in colorectal carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yuan-Feng Zeng, Yi-Sheng Xiao, Yong Liu, Xiao-Jiang Luo, Li-Dan Wen, Qian Liu and Ming Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81201972 |
| Postdoctoral Science Foundation of China |
2013M531555 |
| Postdoctoral Science Foundation of Jiangxi Province |
2013KY44 |
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| Corresponding Author |
Yuan-Feng Zeng, PhD, Chief Doctor, Department of Pathology, Jiangxi Provincial People's Hospital, 152 Patriotic Road, Donghu District, Nanchang 330006, Jiangxi Province, China. zyf760928@163.com |
| Key Words |
Formin-like 3; Colorectal carcinoma; Invasion; RhoC/FAK pathway; Actin assembly |
| Core Tip |
Formin-like 3 (FMNL3) belongs to the subfamily of diaphanous-related formins, which govern the actin-dependent processes, including cell motility and invasion. The increased expression of FMNL3 in colorectal car¬cinoma (CRC) was shown to contribute to metastasis and poor prognosis of patients in previous studies, however its regulatory mechanism remains unclear. This work reveals that FMNL3 plays a positive role in CRC cell proliferation, invasion and migration. Moreover, FMNL3 activates the RhoC/FAK signaling pathway, and also regulates RhoC-dependent remodeling of actin-based protrusion, such as filopodia and lamellipodia, to promote CRC cell invasion. FMNL3 can be applied as a promising specific biomarker for CRC progression and metastasis. |
| Publish Date |
2018-09-14 05:53 |
| Citation |
Zeng YF, Xiao YS, Liu Y, Luo XJ, Wen LD, Liu Q, Chen M. Formin-like 3 regulates RhoC/FAK pathway and actin assembly to promote cell invasion in colorectal carcinoma. World J Gastroenterol 2018; 24(34): 3884-3897 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i34/3884.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i34.3884 |
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