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10/19/2018 4:29:42 AM | Browse: 86 | Download: 40
Publication Name World Journal of Orthopedics
Manuscript ID 39510
Country of Manuscript Source Brazil
Received
2018-05-07 00:29
Peer-Review Started
2018-05-07 01:48
To Make the First Decision
2018-06-15 02:20
Return for Revision
2018-06-19 00:47
Revised
2018-06-20 20:01
Second Decision
2018-06-28 10:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-28 23:46
Articles in Press
2018-06-28 23:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-07-08 02:14
Typeset the Manuscript
2018-10-13 11:25
Publish the Manuscript Online
2018-10-18 11:08
ISSN 2218-5836 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Medicine, Research and Experimental
Manuscript Type Basic Study
Article Title Dose of alendronate directly increases trabeculae expansivity without altering bone volume in rat femurs
Manuscript Source Unsolicited Manuscript
All Author List Suyany G Weiss, Gabrielle O Kuchar, Jennifer T Gerber, Fernanda Tiboni, Carmen Lucia M Storrer, Thaís C Casagrande, Allan F Giovanini and Rafaela Scariot
Funding Agency and Grant Number
Correspondence To Rafaela Scariot, PhD, Associate Professor, School of Health Science, Department of Dentistry, Positivo University, 5300 Professor Pedro Viriato Parigot de Souza Street, Campo Comprido, Curitiba, Paraná 81280-330, Brazil. rafaela.moraes@up.edu.br
Keywords Alendronate; Bone regeneration; Fracture; Femur; Bisphosphonates
Core Tip Several studies have been carried out to determine both the influence of alendronate in bone repair and the appropriate dose of this drug to promote bone regeneration. In this research, 36 Wistar rats were allocated into three distinct groups that received applications of either alendronate at different doses or saline solution three times a week for 45 d. The rats underwent femoral fracture surgery with stable internal fixation. The imaginologic results suggested that the use of alendronate did not have a direct influence on the amount of bone neoformation, however it did influence bone quality in a dose-dependent manner.
Publish Date 2018-10-18 11:08
Citation Weiss SG, Kuchar GO, Gerber JT, Tiboni F, Storrer CLM, Casagrande TC, Giovanini AF, Scariot R. Dose of alendronate directly increases trabeculae expansivity without altering bone volume in rat femurs. World J Orthop 2018; 9(10): 190-197
Url http://www.wjgnet.com/2218-5836/full/v9/i10/190.htm
DOI http://dx.doi.org/10.5312/wjo.v9.i10.190
Full Article (PDF) WJO-9-190.pdf
Full Article (Word) WJO-9-190.doc
Revised Manuscript 39510-Review.docx
Peer-review Report 39510-Peer-review(s).pdf
Answering Reviewers 39510-Answering reviewers.pdf
Scientific Misconduct Check 39510-Scientific misconduct check.pdf
Scientific Editor Work List 39510-Scientific editor work list.pdf
Audio Core Tip 39510-Audio core tip.wav
Biostatistics Review Certificate 39510-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 39510-Conflict-of-interest statement.pdf
Copyright License Agreement 39510-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 39510-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 39510-Language certificate.pdf