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10/12/2018 7:58:37 AM | Browse: 153 | Download: 63
Publication Name World Journal of Gastroenterology
Manuscript ID 40082
Country of Manuscript Source United States
Received
2018-06-21 03:38
Peer-Review Started
2018-06-21 07:36
To Make the First Decision
2018-08-01 02:48
Return for Revision
2018-08-01 07:16
Revised
2018-08-06 16:53
Second Decision
2018-08-20 06:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-08-24 09:19
Articles in Press
2018-08-24 09:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-10-04 02:01
Publish the Manuscript Online
2018-10-12 05:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis
Manuscript Source Unsolicited Manuscript
All Author List Natalia Schneider Nunes, Saejeong Kim, Maggie Sundby, Parwathy Chandran, Scott Robert Burks, Ana Helena Paz and Joseph Alan Frank
Funding Agency and Grant Number
Correspondence To Natalia Schneider Nunes, MSc, Research Fellow, PhD Fellow, Frank Laboratory, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bldg 10 Room B1N256, 10 Center Drive, Bethesda, MD20982, United States. natalia.schneidernunes@nih.gov
Keywords Ulcerative colitis; Dextran sulfate sodium; Proteomics; Inflammatory bowel diseases; Inflammation
Core Tip Our study contributes to a better understanding of the dextran sulfate sodium (DSS) acute colitis model in order to provide a stronger basis for novel therapies. Colonic proteomic temporal analysis reveals an increase in cytokines with a strong influx of immune cells. The highest cytokine levels were observed when animals were no longer drinking DSS, suggesting a rebound response. Secondary lymphoid organs contribute by sending different immune cells to the colon during the acute phase, such as CD4+, CD8+ and CD25+ T cells. Our results demonstrate involvement of the adaptive and innate immune responses during the acute phase of DSS-induced colitis.
Publish Date 2018-10-12 05:32
Citation Nunes NS, Kim S, Sundby M, Chandran P, Burks SR, Paz AH, Frank JA. Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis. World J Gastroenterol 2018; 24(38): 4341-4355
Url http://www.wjgnet.com/1007-9327/full/v24/i38/4341.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i38.4341
Full Article (PDF) WJG-24-4341.pdf
Revised Manuscript 40082-Review.docx
Peer-review Report 40082-Peer-review(s).pdf
Answering Reviewers 40082-Answering reviewers.pdf
Scientific Misconduct Check 40082-Scientific misconduct check.pdf
Scientific Editor Work List 40082-Scientific editor work list.pdf
Audio Core Tip 40082-Audio core tip.mp3
Biostatistics Review Certificate 40082-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 40082-Conflict-of-interest statement.pdf
Copyright License Agreement 40082-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 40082-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 40082-Language certificate.pdf
Supplementary Material 40082-Supplementary material.pdf