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10/9/2018 1:45:07 AM | Browse: 123 | Download: 74
Publication Name World Journal of Gastroenterology
Manuscript ID 40088
Country of Manuscript Source China
Received
2018-05-30 07:09
Peer-Review Started
2018-05-30 08:34
To Make the First Decision
2018-07-12 00:56
Return for Revision
2018-07-18 03:25
Revised
2018-08-09 10:52
Second Decision
2018-08-20 06:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-08-24 09:25
Articles in Press
2018-08-24 09:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-09-05 18:00
Typeset the Manuscript
2018-09-28 08:47
Publish the Manuscript Online
2018-09-30 07:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Potential involvement of heat shock proteins in pancreatic-duodenal homeobox-1-mediated effects on the genesis of gastric cancer: A 2D gel-based proteomic study
Manuscript Source Unsolicited Manuscript
All Author List Juan Ma, Bei-Bei Wang, Xiao-Yan Ma, Wei-Ping Deng, Li-Shu Xu and Wei-Hong Sha
Funding Agency and Grant Number
Funding Agency Grant Number
Guangdong Natural Science Fund; Guangdong General Hospital 2016A030313765
Guangdong medical scientific research fund A2017070 and A2017122
Correspondence To Wei-Hong Sha, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology and Hepatology, Guangdong General Hospital (Guangdong Academy of Medical Sciences), Guangdong Geriatrics Institute, 106 Zhongshan Er Road, Guangzhou 510080, Guangdong Province, China. shaweihong@gdghospital.com.cn
Keywords Pancreatic-duodenal homeobox-1; Heat shock proteins; Gastric cancer; Proteomics; Two-dimensional electrophoresis
Core Tip Using a pcDNA3.1(+)-pancreatic-duodenal homeobox-1 (PDX1) vector, a PDX1-overexpressed model was built. Seven differential proteins were identified in SGC-PDX1 by two-dimensional electrophoresis gel proteomics compared with those in SGC-pcDNA. Four heat shock proteins were identified and confirmed by im­munoblotting. qRT-PCR analysis further revealed that the expression of the HSPs was post-translationally regu­lated by the PDX1 protein. This study suggests the potential involvement of HSPs in PDX1 mediated effects on gastric carcinogenesis.
Publish Date 2018-09-30 07:38
Citation Ma J, Wang BB, Ma XY, Deng WP, Xu LS, Sha WH. Potential involvement of heat shock proteins in pancreatic-duodenal homeobox-1-mediated effects on the genesis of gastric cancer: A 2D gel-based proteomic study. World J Gastroenterol 2018; 24(37): 4263-4271
Url http://www.wjgnet.com/1007-9327/full/v24/i37/4263.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i37.4263
Full Article (PDF) WJG-24-4263.pdf
Full Article (Word) WJG-24-4263.doc
Revised Manuscript 40088-Review.doc
Peer-review Report 40088-Peer-review(s).pdf
Answering Reviewers 40088-Answering reviewers.pdf
Scientific Misconduct Check 40088-Scientific misconduct check.pdf
Scientific Editor Work List 40088-Scientific editor work list.pdf
Audio Core Tip 40088-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 40088-Conflict-of-interest statement.pdf
Copyright License Agreement 40088-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 40088-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 40088-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 40088-Language certificate.pdf