Publication Name	World Journal of Clinical Cases
Manuscript ID	40132
Country	Romania

Received	2018-06-04 01:30
Peer-Review Started	2018-06-04 07:58
To Make the First Decision	2018-08-06 09:08
Return for Revision	2018-08-07 02:44
Revised	2018-08-31 13:32
Second Decision	2018-09-03 08:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-10-08 21:15
Articles in Press	2018-10-08 21:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-10-25 02:54
Publish the Manuscript Online	2018-10-26 14:57

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Treat-to-target in Crohn’s disease: Will transmural healing become a therapeutic endpoint?
Manuscript Source	Invited Manuscript
All Author List	Elena Daniela Serban
Funding Agency and Grant Number
Corresponding Author	Elena Daniela Serban, MD, PhD, Associate Professor, 2nd Department of Pediatrics, "Iuliu Hatieganu" University of Medicine and Pharmacy, Emergency Hospital for Children, 5 Crisan street, Cluj-Napoca 400177, Romania. daniela.serban@umfcluj.ro
Key Words	Treat to target; Cross sectional imaging; Deep remission; Transmural healing; Intestinal healing; Long-term outcomes; Bowel damage; Crohn’s disease
Core Tip	Crohn’s disease (CD) represents a chronic transmural inflammatory condition of the gastrointes­tinal tract, potentially leading to structural damage and disability. Deep remission (clinical and endoscopic remission), the current therapeutic goal, significantly improves patients’ long-term outcomes. Transmural hea­ling (TH) could be a more effective target. Therefore, this narrative review (the first of its kind, to the best of the author’s knowledge) aims to provide the currently available scientific evidence on the predictive role of TH for long-term outcomes (clinical remission, therapeutic changes, CD-related hospitalizations and surgeries) and to establish whether TH should become a therapeutic endpoint in the treat-to-target strategy.
Publish Date	2018-10-26 14:57
Citation	Serban ED. Treat-to-target in Crohn’s disease: Will transmural healing become a therapeutic endpoint? World J Clin Cases 2018; 6(12): 501-513
URL	http://www.wjgnet.com/2307-8960/full/v6/i12/501.htm
DOI	http://dx.doi.org/10.12998/wjcc.v6.i12.501

Full Article (PDF)	WJCC-6-501.pdf
Full Article (Word)	WJCC-6-501.doc
Manuscript File	40132-Review.docx
Answering Reviewers	40132-Answering reviewers.pdf
Audio Core Tip	40132-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	40132-Conflict-of-interest statement.pdf
Copyright License Agreement	40132-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	40132-Language certificate.pdf
Peer-review Report	40132-Peer-review(s).pdf
Scientific Misconduct Check	40132-Scientific misconduct check.pdf
Scientific Editor Work List	40132-Scientific editor work list.pdf