Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	40308
Country	United States

Received	2018-06-21 03:11
Peer-Review Started	2018-06-21 08:43
To Make the First Decision	2018-07-19 07:47
Return for Revision	2018-07-23 06:39
Revised	2018-08-01 17:17
Second Decision	2018-08-18 04:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-08-21 21:10
Articles in Press	2018-08-21 21:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-08-30 18:10
Typeset the Manuscript	2018-09-27 02:38
Publish the Manuscript Online	2018-09-28 00:52

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Kaylene Barrera, Albert Stanek, Kei Okochi, Zuzanna Niewiadomska, Cathy Mueller, Peiqi Ou, Devon John, Antonio E Alfonso, Scott Tenner and Chongmin Huan
Funding Agency and Grant Number
Corresponding Author	Chongmin Huan, MD, PhD, Assistant Professor, Department of Surgery and Cell Biology, State University of New York, Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, United States. chongmin.huan@downstate.edu
Key Words	Acute pancreatitis; Endoplasmic reticulum stress; Unfolded protein response; Acinar cell injury; Autophagy
Core Tip	The widely-accepted autodigestion theory of acute pancreatitis (AP) has been considerably modified by the recent recognition of endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) as an essential self-protective activity in acinar cells. Inadequate UPR, however, leads to acinar cell injury in AP with elusive mechanisms. We review the relevant literature and pro­pose mechanistic models with the hope of facilitating the research required for the development of effective AP treatment.
Publish Date	2018-09-28 00:52
Citation	Barrera K, Stanek A, Okochi K, Niewiadomska Z, Mueller C, Ou P, John D, Alfonso AE, Tenner S, Huan C. Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis. World J Gastrointest Pathophysiol 2018; 9(2): 37-46
URL	http://www.wjgnet.com/2150-5330/full/v9/i2/37.htm
DOI	http://dx.doi.org/10.4291/wjgp.v9.i2.37

Full Article (PDF)	WJGP-9-37.pdf
Manuscript File	40308-Review.docx
Answering Reviewers	40308-Answering reviewers.pdf
Audio Core Tip	40308-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	40308-Conflict-of-interest statement.pdf
Copyright License Agreement	40308-Copyright license agreement.pdf
Peer-review Report	40308-Peer-review(s).pdf
Scientific Misconduct Check	40308-Scientific misconduct check.pdf
Scientific Editor Work List	40308-Scientific editor work list.pdf