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9/4/2018 3:37:06 AM | Browse: 370 | Download: 261
Publication Name World Journal of Clinical Pediatrics
Manuscript ID 40490
Country/Territory Italy
2018-06-27 00:03
Peer-Review Started
2018-06-30 03:49
To Make the First Decision
2018-07-09 08:08
Return for Revision
2018-07-11 02:12
2018-08-06 15:38
Second Decision
2018-08-10 08:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-08-13 03:09
Articles in Press
2018-08-13 03:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-08-18 21:38
Typeset the Manuscript
2018-08-28 10:04
Publish the Manuscript Online
2018-08-30 06:53
ISSN 2219-2808 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pediatrics
Manuscript Type Editorial
Article Title Innovation for rare diseases and bioethical concerns: A thin thread between medical progress and suffering
Manuscript Source Invited Manuscript
All Author List Alberto Tommasini, Andrea Magnolato and Irene Bruno
Funding Agency and Grant Number
Funding Agency Grant Number
IRCCS Burlo Garofolo RC24/17
Corresponding author Alberto Tommasini, MD, PhD, Adjunct Professor, Medical Assistant, Senior Scientist, Department of Pediatrics, Institute of Maternal and Child Health, IRCCS Burlo Garofolo, via dell’Istria 65/1, Trieste 34137, Italy. alberto.tommasini@burlo.trieste.it
Keywords X-severe combined immunodeficiency; Primary immunodeficiency; Beta thalassemia; Spinal muscular atrophy; Bioethics; History of medicine; Precision medicine; Genetics
Core Tip Precision therapies are heralded to change the prognosis of rare and severe genetic disorders. However, the new treatments are not always curative and what can be viewed on one hand as a partial improvement, on the other may result, at least for some patients, in prolonged suffering. During this period of change, great hopes but unpredictable outcomes can mark the lives of patients. Recalling and considering the ethical debates on historical cases can help doctors in giving the right advice to the families of patients with rare and severe disorders.
Publish Date 2018-08-30 06:53
Citation Tommasini A, Magnolato A, Bruno I. Innovation for rare diseases and bioethical concerns: A thin thread between medical progress and suffering. World J Clin Pediatr 2018; 7(3): 75-82
Url http://www.wjgnet.com/2219-2808/full/v7/i3/75.htm
DOI http://dx.doi.org/10.5409/wjcp.v7.i3.75
Full Article (PDF) WJCP-7-75.pdf
Full Article (Word) WJCP-7-75.doc
Manuscript File 40490-Review.docx
Answering Reviewers 40490-Answering reviewers.pdf
Audio Core Tip 40490-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 40490-Conflict-of-interest statement.pdf
Copyright License Agreement 40490-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 40490-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 40490-Language certificate.pdf
Peer-review Report 40490-Peer-review(s).pdf
Scientific Misconduct Check 40490-Scientific misconduct check.pdf
Scientific Editor Work List 40490-Scientific editor work list.pdf