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1/27/2019 7:53:50 AM | Browse: 923 | Download: 1073
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Received |
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2018-07-26 05:56 |
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Peer-Review Started |
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2018-07-26 08:07 |
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First Decision by Editorial Office Director |
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2018-10-05 13:11 |
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Return for Revision |
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2018-10-09 06:58 |
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Revised |
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2018-12-07 06:27 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2018-12-14 10:00 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2018-12-15 02:26 |
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Articles in Press |
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2018-12-15 02:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-01-25 02:16 |
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Publish the Manuscript Online |
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2019-01-26 11:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Differentiating Crohn’s disease from intestinal tuberculosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Saurabh Kedia, Prasenjit Das, Kumble Seetharama Madhusudhan, Siddhartha Dattagupta, Raju Sharma, Peush Sahni, Govind K Makharia and Vineet Ahuja |
| Funding Agency and Grant Number |
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| Corresponding Author |
Saurabh Kedia, MD, Assistant Professor, Department of Gastroenterology, All India Institute of Medical Sciences, Room No 3066, Third Floor, Teaching Block, New Delhi 110029, India. dr.saurabhkedia@yahoo.com |
| Key Words |
Crohn's disease; Intestinal tuberculosis; Endoscopy; Computed tomographic enterography; Granuloma |
| Core Tip |
There is a constant challenge of differentiating Crohn’s disease (CD) from intestinal tuberculosis, especially with the increasing burden of inflammatory bowel disease in tuberculosis-endemic areas. Caseation necrosis on biopsy, positive acid-fast bacillus smear/culture, and necrotic lymph node on computed tomography (CT) are the only differentiating features with 100% specificity, though are limited by poor sensitivity. Multi-parametric models have their own limitations and a therapeutic trial of anti-tubercular therapy is often required. Upcoming markers include the latest Bayesian meta-analysis, enumeration of peripheral blood T-regulatory cells, and updated CT based predictive score. Therapeutic trial is associated with a delay in CD diagnosis, and better modalities/biomarkers are required for improved differentiation and reduction in the need for anti-tubercular therapy trial. |
| Publish Date |
2019-01-26 11:40 |
| Citation |
Kedia S, Das P, Madhusudhan KS, Dattagupta S, Sharma R, Sahni P, Makharia G, Ahuja V. Differentiating Crohn’s disease from intestinal tuberculosis. World J Gastroenterol 2019; 25(4): 418-432 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i4/418.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i4.418 |
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