Publication Name	World Journal of Diabetes
Manuscript ID	41008
Country	United States

Received	2018-07-19 02:20
Peer-Review Started	2018-07-19 12:59
To Make the First Decision	2018-08-09 00:41
Return for Revision	2018-08-13 01:52
Revised	2018-10-08 02:34
Second Decision	2018-10-23 03:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-10-24 00:18
Articles in Press	2018-10-24 00:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-11-09 02:58
Publish the Manuscript Online	2018-11-14 01:33

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Field of Vision
Article Title	Circadian rhythms of hormone secretion and obesity
Manuscript Source	Invited Manuscript
All Author List	Rajendra Raghow
Funding Agency and Grant Number
Corresponding Author	Rajendra Raghow, PhD, Professor, Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, United States. rraghow@uthsc.edu
Key Words	Circadian rhythms; Glucocorticoids; Adipose tissue; Pre-adipocytes; Stem cells; Terminal differentiation
Core Tip	Bahrami-Nejad et al examined pre-adipocytes for their ability to differentiate into fat cells in response to hormonal stimuli that were presented either in a pulsatile manner, mimicking circadian rhythms, or de­livered continuously. These experiments revealed that adipocyte differentiation program, made up of slow and fast feedback circuits, was able to distinguish between the oscillating and continuous hormonal signals. The authors showed that pre-adipocytes apparently used the fast, positive feedback network to reject the oscillating hormonal cues. In contrast, if delivered continuously, similar strength glucocorticoids impinged on the slow positive feedback circuit to trigger maximal differentia­tion of pre-adipocytes into bone fide fat cells. The pulsatile vs continuous hormone stimuli were similarly discriminated in vivo since mice receiving glucocorticoids in a non-oscillating manner for 21 d elicited increased accumulation of subcutaneous and visceral fat. These data elucidate a potential mechanism underling the development of obesity associated with chronic stress or Cushing’s disease.
Publish Date	2018-11-14 01:33
Citation	Raghow R. Circadian rhythms of hormone secretion and obesity. World J Diabetes 2018; 9(11): 195-198
URL	http://www.wjgnet.com/1948-9358/full/v9/i11/195.htm
DOI	http://dx.doi.org/10.4239/wjd.v9.i11.195

Full Article (PDF)	WJD-9-195.pdf
Full Article (Word)	WJD-9-195.doc
Manuscript File	41008-Review.docx
Answering Reviewers	41008-Answering reviewers.pdf
Audio Core Tip	41008-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	41008-Conflict-of-interest statement.pdf
Copyright License Agreement	41008-Copyright license agreement.pdf
Peer-review Report	41008-Peer-review(s).pdf
Scientific Misconduct Check	41008-Scientific misconduct check.pdf
Scientific Editor Work List	41008-Scientific editor work list.pdf