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12/26/2018 3:20:17 AM | Browse: 809 | Download: 931
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Received |
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2018-08-09 08:36 |
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Peer-Review Started |
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2018-08-09 09:04 |
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To Make the First Decision |
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2018-09-03 01:05 |
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Return for Revision |
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2018-09-03 08:28 |
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Revised |
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2018-10-18 02:01 |
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Second Decision |
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2018-11-07 11:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-11-07 19:04 |
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Articles in Press |
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2018-11-07 19:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-11-13 18:12 |
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Typeset the Manuscript |
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2018-12-18 08:36 |
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Publish the Manuscript Online |
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2018-12-25 02:53 |
| ISSN |
1948-0210 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Platelet-rich plasma enhances adipose-derived stem cell-mediated angiogenesis in a mouse ischemic hindlimb model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chia-Fang Chen and Han-Tsung Liao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant of National Sci-Tech Program, Ministry of Science and Technology |
NRMPG3E0471 and NMRPG3D0231 |
| Chang Gung Memorial Hospital |
CMRPGBH0011 |
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| Corresponding Author |
Han-Tsung Liao, MD, PhD, Associate Professor, Chief Doctor, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, No.5 Fusing Street, Taoyuan 333, Taiwan. lia01211@gmail.com |
| Key Words |
Platelet-rich plasma; Adipose-derived stem cells; Mesenchymal stem cell; Angiogenesis; Endothelial differentiation; Mouse ischemic hindlimb model |
| Core Tip |
We reported the in vitro angiogenic effect of platelet-rich plasma (PRP) treated adipose-derived stem cells (ADSCs) and the neovascularization ability of these cells in animal models. This is significant because we demonstrated that ADSCs presented endothelial cell characteristics after PRP treatment. We were the first to observe that treatment with PRP-preconditioned ADSCs significantly enhanced circulation in mouse ischemic hindlimbs models. Our result further showed that 5% and 7.5% PRP exerted the optimal effect on promoting angiogenesis of ADSCs and improving perfusion. We developed a stem cell-based, safe, and efficient way to promote peripheral circulation in animal model. |
| Publish Date |
2018-12-25 02:53 |
| Citation |
Chen CF, Liao HT. Platelet-rich plasma enhances adipose-derived stem cell-mediated angiogenesis in a mouse ischemic hindlimb model. World J Stem Cells 2018; 10(12): 212-227 |
| URL |
https://www.wjgnet.com/1948-0210/full/v10/i12/212.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v10.i12.212 |
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