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12/26/2018 3:20:17 AM | Browse: 155 | Download: 132
Publication Name World Journal of Stem Cells
Manuscript ID 41389
Country of Manuscript Source Taiwan
Received
2018-08-09 08:36
Peer-Review Started
2018-08-09 09:04
To Make the First Decision
2018-09-03 01:05
Return for Revision
2018-09-03 08:28
Revised
2018-10-18 02:01
Second Decision
2018-11-07 11:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-07 19:04
Articles in Press
2018-11-07 19:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-11-13 18:12
Typeset the Manuscript
2018-12-18 08:36
Publish the Manuscript Online
2018-12-25 02:53
ISSN 1948-0210 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Cell Biology
Manuscript Type Basic Study
Article Title Platelet-rich plasma enhances adipose-derived stem cell-mediated angiogenesis in a mouse ischemic hindlimb model
Manuscript Source Unsolicited Manuscript
All Author List Chia-Fang Chen and Han-Tsung Liao
Funding Agency and Grant Number
Funding Agency Grant Number
Grant of National Sci-Tech Program, Ministry of Science and Technology NRMPG3E0471 and NMRPG3D0231
Chang Gung Memorial Hospital CMRPGBH0011
Correspondence To Han-Tsung Liao, MD, PhD, Associate Professor, Chief Doctor, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, No.5 Fusing Street, Taoyuan 333, Taiwan. lia01211@gmail.com
Keywords Platelet-rich plasma; Adipose-derived stem cells; Mesenchymal stem cell; Angiogenesis; Endothelial differentiation; Mouse ischemic hindlimb model
Core Tip We reported the in vitro angiogenic effect of platelet-rich plasma (PRP) treated adipose-derived stem cells (ADSCs) and the neovascularization ability of these cells in animal models. This is significant be­ca­use we demonstrated that ADSCs presented endothelial cell characteristics after PRP treatment. We were the first to observe that treatment with PRP-preconditioned ADSCs significantly enhanced circulation in mouse ischemic hindlimbs models. Our result further showed that 5% and 7.5% PRP exerted the optimal effect on promoting angiogenesis of ADSCs and improving perfusion. We developed a stem cell-based, safe, and efficient way to promote peripheral circulation in animal model.
Publish Date 2018-12-25 02:53
Citation Chen CF, Liao HT. Platelet-rich plasma enhances adipose-derived stem cell-mediated angiogenesis in a mouse ischemic hindlimb model. World J Stem Cells 2018; 10(12): 212-227
Url https://www.wjgnet.com/1948-0210/full/v10/i12/212.htm
DOI https://dx.doi.org/10.4252/wjsc.v10.i12.212
Full Article (PDF) WJSC-10-212.pdf
Full Article (Word) WJSC-10-212.docx
Manuscript File 41389-Review.docx
Peer-review Report 41389-Peer-review(s).pdf
Answering Reviewers 41389-Answering reviewers.pdf
Scientific Misconduct Check 41389-Scientific misconduct check.pdf
Scientific Editor Work List 41389-Scientific editor work list.pdf
Audio Core Tip 41389-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 41389-Conflict-of-interest statement.pdf
Copyright License Agreement 41389-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41389-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 41389-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 41389-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 41389-Language certificate.pdf