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1/16/2019 5:14:02 AM | Browse: 405 | Download: 975
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Received |
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2018-08-28 06:34 |
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Peer-Review Started |
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2018-08-28 12:41 |
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To Make the First Decision |
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2018-10-17 01:47 |
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Return for Revision |
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2018-10-17 05:58 |
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Revised |
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2018-11-20 16:51 |
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Second Decision |
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2018-11-23 10:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-11-26 19:42 |
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Articles in Press |
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2018-11-26 19:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-12-04 20:53 |
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Typeset the Manuscript |
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2018-12-21 04:41 |
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Publish the Manuscript Online |
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2018-12-26 09:35 |
| ISSN |
1949-8462 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Cardiac implications of thrombotic thrombocytopenic purpura
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Szymon L. Wiernek, Bo Jiang, Gregory M. Gustafson and Xuming Dai |
| Funding Agency and Grant Number |
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| Corresponding Author |
Xuming Dai, FACC, MD, PhD, Attending Doctor, Division of Cardiology, New York Presbyterian Medical Group - Queens Hospital, 56-45 Main Street, Flushing, NY 11355, United States. xud9002@nyp.org |
| Key Words |
Thrombotic thrombocytopenic purpura; Acute myocardial infarction; Coronary artery disease; Anti-platelet therapy; von Willebrand factor; ADAMTS13 |
| Core Tip |
Thrombotic thrombocytopenic purpura (TTP) is a grave medical condition caused by the formation of von Willebrand factor multimers that cause large platelet plugs and diffuse microemboli, leading to life-threatening, multi-organ ischemic injuries. Although cardiac involvement commonly occurs related to TTP, these cardiac manifestations have not been well studied and may thus be overlooked in clinical practice. Management of cardiac ischemia or myocardial infarction in TTP is also challenging due to increased hemorrhagic risk in the setting of thrombocytopenia. In this report, we systematically review available clinical data in the literature and summarize clinical manifestation, diagnostic workup strategies, prognosis, and the outcomes of cardiac involvement of TTP. We provide recommendations on the strategies for clinical assessment and management of TTP patients with cardiac involvement. |
| Publish Date |
2018-12-26 09:35 |
| Citation |
Wiernek SL, Jiang B, Gustafason GM, Dai X. Cardiac implications of thrombotic thrombocytopenic purpura. World J Cardiol 2018; 10(12): 254-266 |
| URL |
https://www.wjgnet.com/1949-8462/full/v10/i12/254.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v10.i12.254 |
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