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Publication Name World Journal of Cardiology
Manuscript ID 41753
Country/Territory United States
Received
2018-08-28 06:34
Peer-Review Started
2018-08-28 12:41
To Make the First Decision
2018-10-17 01:47
Return for Revision
2018-10-17 05:58
Revised
2018-11-20 16:51
Second Decision
2018-11-23 10:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-26 19:42
Articles in Press
2018-11-26 19:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-12-04 20:53
Typeset the Manuscript
2018-12-21 04:41
Publish the Manuscript Online
2018-12-26 09:35
ISSN 1949-8462 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Review
Article Title Cardiac implications of thrombotic thrombocytopenic purpura
Manuscript Source Invited Manuscript
All Author List Szymon L. Wiernek, Bo Jiang, Gregory M. Gustafson and Xuming Dai
Funding Agency and Grant Number
Corresponding Author Xuming Dai, FACC, MD, PhD, Attending Doctor, Division of Cardiology, New York Presbyterian Medical Group - Queens Hospital, 56-45 Main Street, Flushing, NY 11355, United States. xud9002@nyp.org
Key Words Thrombotic thrombocytopenic purpura; Acute myocardial infarction; Coronary artery disease; Anti-platelet therapy; von Willebrand factor; ADAMTS13
Core Tip Thrombotic thrombocytopenic purpura (TTP) is a grave medical condition caused by the formation of von Willebrand factor multimers that cause large platelet plugs and diffuse microemboli, leading to life-threatening, multi-organ ischemic injuries. Although cardiac involvement commonly occurs related to TTP, these cardiac manifestations have not been well studied and may thus be overlooked in clinical practice. Management of cardiac ischemia or myocardial infarction in TTP is also challenging due to increased hemorrhagic risk in the setting of thrombocytopenia. In this report, we systematically review available clinical data in the literature and summarize clinical manifestation, diagnostic workup strategies, prognosis, and the outcomes of cardiac involvement of TTP. We provide recommendations on the strategies for clinical assessment and management of TTP patients with cardiac involvement.
Publish Date 2018-12-26 09:35
Citation Wiernek SL, Jiang B, Gustafason GM, Dai X. Cardiac implications of thrombotic thrombocytopenic purpura. World J Cardiol 2018; 10(12): 254-266
URL https://www.wjgnet.com/1949-8462/full/v10/i12/254.htm
DOI https://dx.doi.org/10.4330/wjc.v10.i12.254
Full Article (PDF) WJC-10-254.pdf
Full Article (Word) WJC-10-254.docx
Manuscript File 41753-Review.docx
Answering Reviewers 41753-Answering reviewers.pdf
Audio Core Tip 41753-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 41753-Conflict-of-interest statement.pdf
Copyright License Agreement 41753-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41753-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s)-revision.pdf
Non-Native Speakers of English Editing Certificate 41753-Language certificate.pdf
Peer-review Report 41753-Peer-review(s).pdf
Scientific Misconduct Check 41753-Scientific misconduct check.pdf
Scientific Editor Work List 41753-Scientific editor work list.pdf