Publication Name	World Journal of Clinical Cases
Manuscript ID	41854
Country	Canada

Received	2018-09-05 02:26
Peer-Review Started	2018-09-06 02:26
To Make the First Decision	2018-10-12 00:22
Return for Revision	2018-10-19 07:43
Revised	2019-02-05 06:36
Second Decision	2019-02-26 10:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-02-26 18:27
Articles in Press	2019-02-26 18:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-03-07 20:25
Typeset the Manuscript	2019-03-24 06:25
Publish the Manuscript Online	2019-03-26 03:26

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Liver involvement in the drug reaction, eosinophilia and systemic symptoms syndrome
Manuscript Source	Invited Manuscript
All Author List	Sylvia Aide Martinez-Cabriales, Neil H Shear and Emmanuel Irineo Gonzalez-Moreno
Funding Agency and Grant Number
Corresponding Author	Emmanuel Irineo Gonzalez-Moreno, MD, Assistant Professor, Staff Physician, Department of Medicine, Division of Gastroenterology, University of Calgary, Teaching, Research, and Wellness Building, 6D58, 3280 Hospital Drive NW, Alberta T2N 4Z6, Calgary, Canada. emmanuel_gomo@hotmail.com
Key Words	Drug reaction, eosinophilia and systemic symptoms syndrome; Severe cutaneous drug reactions; Drug-induced hypersensitivity syndrome; Drug-induced liver injury; Acute liver failure
Core Tip	Drug reaction, eosinophilia and systemic symptoms syndrome (DReSS) is considered a severe cutaneous drug reaction. It can present with a broad spectrum of clinical manifestations making its diagnosis challenging. Factors associated with a poor prognosis include delayed diagnosis, viral reactivation, the presence of systemic inflammatory response syndrome, and severe organ involvement. Liver injury, presented in more than half of patient with DReSS, ranges from mild transaminasemia to acute liver failure, being one of the most common causes of death in these patients. Prompt withdrawal of the culprit agent and a multidisciplinary approach in patients with internal organ affection are of utmost importance.
Publish Date	2019-03-26 03:26
Citation	Martinez-Cabriales SA, Shear NH, Gonzalez-Moreno EI. Liver involvement in the drug reaction, eosinophilia and systemic symptoms syndrome. World J Clin Cases 2019; 7(6): 705-716
URL	https://www.wjgnet.com/2307-8960/full/v7/i6/705.htm
DOI	https://dx.doi.org/10.12998/wjcc.v7.i6.705

Full Article (PDF)	WJCC-7-705.pdf
Full Article (Word)	WJCC-7-705.docx
Manuscript File	FINAL MARCH FP6788_de16_CE1MS_edit2.docx
Answering Reviewers	41854-Answering reviewers.pdf
Audio Core Tip	41854-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	41854-Conflict-of-interest statement.pdf
Copyright License Agreement	41854-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	41854-Language certificate.pdf
Peer-review Report	41854-Peer-review(s).pdf
Scientific Misconduct Check	41854-Scientific misconduct check.pdf
Scientific Editor Work List	41854-Scientific editor work list.pdf
CrossCheck Report	41854-CrossCheck report.pdf