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12/26/2018 3:20:15 AM | Browse: 644 | Download: 815
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Received |
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2018-09-10 07:10 |
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Peer-Review Started |
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2018-09-10 07:31 |
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To Make the First Decision |
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2018-10-12 00:26 |
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Return for Revision |
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2018-10-12 07:39 |
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Revised |
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2018-10-17 18:53 |
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Second Decision |
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2018-11-07 09:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-11-07 22:30 |
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Articles in Press |
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2018-11-07 22:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-11-13 21:31 |
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Typeset the Manuscript |
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2018-12-04 06:26 |
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Publish the Manuscript Online |
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2018-12-24 01:07 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Randomized Clinical Trial |
| Article Title |
Effect of clonidine on the cutaneous silent period during spinal anesthesia
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sandra Graf Zupcic, Miroslav Zupcic, Viktor Duzel, Tatjana Šimurina, Milan Milošević, Silvio Basic, Vladimira Vuletic and Leonardo Kapural |
| Funding Agency and Grant Number |
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| Corresponding Author |
Miroslav Zupcic, MD, PhD, Assistant Professor, Clinic of Anesthesiology and Intensive Care Medicine, Clinical Hospital Centre Rijeka, Kresimirova Ulica 42, Rijeka 51000, Croatia. miro_zupcic@yahoo.com |
| Key Words |
Clonidine; Local anesthetics; Nerve fibers; Spinal anesthesia; Reflex |
| Core Tip |
Cutaneous silent period (CSP) is an oligo¬synaptic spinal inhibitory reflex. The results of our study show that intrathecal administration of levobupivacaine with added clonidine, in comparison to levobupivacaine alone, yields a significantly shorter CSP and a significantly longer CSP latency during block regression following subarachnoid block (SAB) application. Accordingly, we can conclude that during SAB regression, a small dose of intrathecally administered clonidine ameliorates the inhibitory tonus and accelerates the conduction in the oligosynaptic spinal circuit. |
| Publish Date |
2018-12-24 01:07 |
| Citation |
Graf Zupcic S, Zupcic M, Duzel V, Šimurina T, Milošević M, Basic S, Vuletic V, Kapural L. Effect of clonidine on the cutaneous silent period during spinal anesthesia. World J Clin Cases 2018; 6(16): 1136-1145 |
| URL |
https://www.wjgnet.com/2307-8960/full/v6/i16/1136.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v6.i16.1136 |
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