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2/19/2019 9:59:03 AM | Browse: 460 | Download: 664
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Received |
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2018-09-19 05:50 |
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Peer-Review Started |
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2018-09-19 08:11 |
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To Make the First Decision |
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2018-10-17 01:44 |
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Return for Revision |
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2018-10-18 00:37 |
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Revised |
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2018-12-11 10:15 |
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Second Decision |
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2019-01-08 11:29 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-01-10 19:04 |
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Articles in Press |
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2019-01-10 19:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-01-29 02:22 |
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Typeset the Manuscript |
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2019-02-15 01:24 |
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Publish the Manuscript Online |
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2019-02-15 09:46 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Redox, immune and genetic biomarker’s system for personalized treatments in colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anna Maria Berghella, Anna Aureli, Angelica Canossi, Tiziana Del Beato, Alessia Colanardi and Patrizia Pellegrini |
| Funding Agency and Grant Number |
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| Corresponding Author |
Anna Maria Berghella, PhD, Research Scientist, Consiglio Nazionale delle Ricerche (CNR), Istituto di Farmacologia Traslazionale (IFT), via G Carducci, 32, L'Aquila 67100, AQ, Italy. annamaria.berghella@cnr.it |
| Key Words |
Aging and cancer biomarker; Cancer personalized treatments; Oxidation and immune biomarkers; Trx1/CD30 target; KIRs and FcR polymorphisms; Th cytokines; Aging and disease; Cancer-related mechanisms |
| Core Tip |
Identifying biomarkers able of point out the risk of development of degenerative processes linked to aging and colorectal cancer (CRC) onset, could improve clinical strategies. The aim was to establish if Trx1 and CD30 as dual target, combined with cytokines and polymorphisms of KIRs, FcRIIa-131H/R and FcRIIIa-158V/F, was more effective. Serum measures of Trx1/CD30, RTrx1, multiple cytokine levels and polymorphisms of KIR and FcγRIIa were used to estimate the effect of disease, age and gender to describe the variants in the biology of the redox immune system. Through these procedures, the redox immune fingerprint of health, ageing and cancer states was determined. |
| Publish Date |
2019-02-15 09:46 |
| Citation |
Berghella AM, Aureli A, Canossi A, Del Beato T, Colanardi A, Pellegrini P. Redox, immune and genetic biomarker’s system for personalized treatments in colorectal cancer. World J Gastrointest Oncol 2019; 11(2): 117-138 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i2/117.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i2.117 |
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