Publication Name	World Journal of Orthopedics
Manuscript ID	42717
Country	Italy

Received	2018-10-07 06:02
Peer-Review Started	2018-10-07 11:40
To Make the First Decision	2018-10-22 00:28
Return for Revision	2018-10-24 01:44
Revised	2018-12-26 18:41
Second Decision	2019-01-03 11:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-06 03:59
Articles in Press	2019-01-06 03:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-02-18 00:23
Publish the Manuscript Online	2019-02-18 04:17

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Allergy in total knee replacement surgery: Is it a real problem?
Manuscript Source	Invited Manuscript
All Author List	Maristella Francesca Saccomanno, Giuseppe Sircana, Giulia Masci, Gianpiero Cazzato, Michela Florio, Luigi Capasso, Marco Passiatore, Giovanni Autore, Giulio Maccauro and Enrico Pola
Funding Agency and Grant Number
Corresponding Author	Enrico Pola, MD, PhD, Academic Research, Associate Professor, Doctor, Professor, Department of Orthopedics and Traumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go Agostino Gemelli, 8, Rome 00168, Italy. enrico.pola@tiscali.it
Key Words	Knee arthroplasty; Total knee arthroplasty; Metal hypersensitivity; Metal allergy; Non-allergenic implants
Core Tip	Metal hypersensitivity may be a cause of failure for total knee arthroplasty, although a clear correlation between metal sensitization and symptomatic knee after surgery has not been ascertained. Patients with a clear history of metal allergy, must be carefully examined through dermatological and laboratory testing before surgery. However, despite the increase in cutaneous and systemic hypersensitivity reactions to metals, which raise concern about joint arthroplasties, allergies against implant materials remain quite rare and an unexplored issue.
Publish Date	2019-02-18 04:17
Citation	Saccomanno MF, Sircana G, Masci G, Cazzato G, Florio M, Capasso L, Passiatore M, Autore G, Maccauro G, Pola E. Allergy in total knee replacement surgery: Is it a real problem? World J Orthop 2019; 10(2): 63-70
URL	https://www.wjgnet.com/2218-5836/full/v10/i2/63.htm
DOI	https://dx.doi.org/10.5312/wjo.v10.i2.63

Full Article (PDF)	WJO-10-63.pdf
Full Article (Word)	WJO-10-63.docx
Manuscript File	42717-Review.docx
Answering Reviewers	42717-Answering reviewers.pdf
Audio Core Tip	42717-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	42717-Conflict-of-interest statement.pdf
Copyright License Agreement	42717-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	42717-Language certificate.pdf
Peer-review Report	42717-Peer-review(s).pdf
Scientific Misconduct Check	42717-Scientific misconduct check.pdf
Scientific Editor Work List	42717-Scientific editor work list.pdf