Publication Name	World Journal of Clinical Cases
Manuscript ID	43221
Country	Romania

Received	2018-10-30 01:53
Peer-Review Started	2018-10-31 02:26
To Make the First Decision	2018-11-16 01:07
Return for Revision	2018-11-29 07:06
Revised	2018-12-18 19:16
Second Decision	2018-12-21 09:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-12-24 02:38
Articles in Press	2018-12-24 02:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-01-25 05:27
Publish the Manuscript Online	2019-01-29 02:00

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Prospective Study
Article Title	Split-dose or hybrid nonsteroidal anti-inflammatory drugs and N-acetylcysteine therapy for prevention of post-retrograde cholangiopancreatography pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Laura Pavel, Gheorghe Gh Bălan, Alexandra Nicorescu, Georgiana Emmanuela Gîlcă-Blanariu, Cătălin Sfarti, Ștefan Chiriac, Smaranda Diaconescu, Vasile Liviu Drug, Gheorghe Bălan and Gabriela Ștefănescu
Funding Agency and Grant Number
Corresponding Author	Smaranda Diaconescu, MD, PhD, Associate Professor, Department of Mother and Child Medicine, “Grigore T. Popa” University Of Medicine and Pharmacy, 16 Universității str, Iasi 700115, Romania. turti23@yahoo.com
Key Words	Endoscopic retrograde cholangiopancreatography; Prophylaxis; Post-ERCP pancreatitis; Nonsteroidal anti-inflammatory drugs; N-acetylcysteine
Core Tip	Despite significant technical and training improvements, the incidence of post-endoscopic retrograde-cholangiopancreatography (ERCP) pancreatitis has not dropped significantly. The present prospective, single-center randomized trial aimed to evaluate the efficacy of three prophylactic approaches for preventing post-ERCP pancreatitis. The results obtained demonstrate that the efficacies for preventing post-ERCP pancreatitis for both split-dose administration of indomethacin and combined administration of N-acetylcysteine before the procedure with administration of indomethacin post-ERCP are similar to that of the guideline-recommended regimen; although, a slightly more rapid improvement in the biological response was observed for the study group receiving the combination therapy (nonsteroidal anti-inflammatory drugs associated with N-acetylcysteine).
Publish Date	2019-01-29 02:00
Citation	Pavel L, Bălan GG, Nicorescu A, Gîlcă-Blanariu GE, Sfarti C, Chiriac Ș, Diaconescu S, Drug VL, Bălan G, Ștefănescu G. Split-dose or hybrid nonsteroidal anti-inflammatory drugs and N-acetylcysteine therapy for prevention of post-retrograde cholangiopancreatography pancreatitis. World J Clin Cases 2019; 7(3): 300-310
URL	https://www.wjgnet.com/2307-8960/full/v7/i3/300.htm
DOI	https://dx.doi.org/10.12998/wjcc.v7.i3.300

Full Article (PDF)	WJCC-7-300.pdf
Full Article (Word)	WJCC-7-300.docx
CONSORT 2010 Statement	43221-CONSORT 2010 statement.pdf
Manuscript File	43221-Review.docx
Answering Reviewers	43221-Answering reviewers.pdf
Audio Core Tip	43221-Audio core tip.mp3
Biostatistics Review Certificate	43221-Biostatistics statement.pdf
Clinical Trial Registration Statement	43221-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	43221-Conflict-of-interest statement.pdf
Copyright License Agreement	43221-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	43221-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	43221-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	43221-Language certificate.pdf
Peer-review Report	43221-Peer-review(s).pdf
Scientific Misconduct Check	43221-Scientific misconduct check.pdf
Scientific Editor Work List	43221-Scientific editor work list.pdf