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2/19/2019 9:59:03 AM | Browse: 592 | Download: 777
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Received |
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2018-11-12 01:10 |
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Peer-Review Started |
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2018-11-14 09:02 |
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To Make the First Decision |
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2018-12-11 01:12 |
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Return for Revision |
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2018-12-17 02:55 |
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Revised |
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2018-12-22 01:00 |
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Second Decision |
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2019-01-08 13:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-01-09 02:04 |
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Articles in Press |
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2019-01-09 02:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-01-19 22:43 |
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Typeset the Manuscript |
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2019-02-15 01:30 |
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Publish the Manuscript Online |
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2019-02-15 09:46 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Novel long non-coding RNA LINC02532 promotes gastric cancer cell proliferation, migration, and invasion in vitro
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng Zhang, Ming-Hui Ma, Yu Liang, Kun-Zhe Wu and Dong-Qiu Dai |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
30572162 |
| Natural Science Foundation of Liaoning Province |
201602817 |
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| Corresponding Author |
Dong-Qiu Dai, PhD, Chief Doctor, Professor, Surgical Oncologist, Department of Gastroenterological Surgery, The Fourth Affiliated Hospital of China Medical University, 4 Chongshan Road, Shenyang 110032, Liaoning Province, China. daidq63@163.com |
| Key Words |
Gastric cancer; Long noncoding RNA; LINC02532; Prognosis; Bioinformatics |
| Core Tip |
Our study identified a novel long non-coding RNA LINC02532 and found that it was significantly overexpressed in gastric cancer (GC). Kaplan–Meier survival analysis showed that patients with higher LINC02532 expression had poorer prognosis than those with lower LINC02532 expression. The correlation analysis between expression and clinicopathological features revealed that the high expression of LINC02532 was associated with a high TNM stage and poor differentiation grade. Functional assays supported the finding that LINC02532 promoted GC cells proliferation, migration, and invasion. According to the bioinformatics analysis, LINC02532 may sponge downregulated miR-129-5p and miR-490-5p and participate in transcriptional misregulation in cancer, cell cycle, and TGF-beta, and mTOR and p53 signaling pathways. |
| Publish Date |
2019-02-15 09:46 |
| Citation |
Zhang C, Ma MH, Liang Y, Wu KZ, Dai DQ. Novel long non-coding RNA LINC02532 promotes gastric cancer cell proliferation, migration, and invasion in vitro. World J Gastrointest Oncol 2019; 11(2): 91-101 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i2/91.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i2.91 |
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