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6/28/2019 8:01:23 AM | Browse: 596 | Download: 162
Publication Name World Journal of Hepatology
Manuscript ID 44619
Country of Manuscript Source Singapore
Received
2019-02-12 01:39
Peer-Review Started
2019-02-13 10:31
To Make the First Decision
2019-04-02 02:38
Return for Revision
2019-04-11 03:55
Revised
2019-06-11 10:45
Second Decision
2019-06-14 07:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-17 20:50
Articles in Press
2019-06-17 20:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-06-24 00:12
Typeset the Manuscript
2019-06-27 08:27
Publish the Manuscript Online
2019-06-27 10:40
ISSN 1948-5182 (online)
Open Access
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Retrospective Study
Article Title Risk factors for ribavirin treatment failure in Asian organ transplant recipients with chronic hepatitis E infection
Manuscript Source Unsolicited Manuscript
All Author List En Xian Sarah Low, Edhel Tripon, Kieron Lim, Poh Seng Tan, How Cheng Low, Yock Young Dan, Yin Mei Lee, Mark Muthiah, Wai Mun Loo, Calvin Jianyi Koh, Wah Wah Phyo, Junxiong Pang, Seng Gee Lim and Guan Huei Lee
Funding Agency and Grant Number
Correspondence To Guan Huei Lee, MBBS, MRCP, PhD, Attending Doctor, Division of Gastroenterology and Hepatology, National University Health System, 1E, Kent Ridge Road, Singapore 119228, Singapore. guan_huei_lee@nuhs.edu.sg
Keywords Toxicity; Antiviral agents; Hepatitis E virus; Virus classification; Systemic immunity; Immune responses; Persistent infection
Core Tip Hepatitis E virus (HEV) infection is a cause of chronic hepatitis in immunosuppressed patients. Sustained virologic response (SVR) rate to a 12-wk course of ribavirin therapy was reported to be > 70% in the West. This study describes the outcome of HEV treatment in a transplant center in Singapore. Ten transplant recipients (liver, kidney, bone marrow transplantation) with positive HEV RNA are studied. The SVR rate of 12-wk ribavirin therapy for HEV infection in this Asian series is lower than expected - overall failure rate (66.7%). Kidney transplant recipients have more treatment failure due to higher immunosuppression requirements and adverse effects.
Publish Date 2019-06-27 10:40
Citation Low EXS, Tripon E, Lim K, Tan PS, Low HC, Dan YY, Lee YM, Muthiah M, Loo WM, Koh CJ, Phyo WW, Pang JX, Lim SG, Lee GH. Risk factors for ribavirin treatment failure in Asian organ transplant recipients with chronic hepatitis E infection. World J Hepatol 2019; 11(6): 553-561
Url https://www.wjgnet.com/1948-5182/full/v11/i6/553.htm
DOI https://dx.doi.org/10.4254/wjh.v11.i6.553
Full Article (PDF) WJH-11-553.pdf
Full Article (Word) WJH-11-553.docx
Manuscript File FP6884_de25_CE1MS-edit2.docx
Answering Reviewers 44619-Answering reviewers.pdf
Audio Core Tip 44619-Audio core tip.mp3
Biostatistics Review Certificate 44619-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 44619-Conflict-of-interest statement.pdf
Copyright License Agreement 44619-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 44619-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 44619-Institutional review board statement.pdf
Peer-review Report 44619-Peer-review(s).pdf
Scientific Misconduct Check 44619-Scientific misconduct check.pdf
Scientific Editor Work List 44619-Scientific editor work list.pdf