Publication Name	World Journal of Gastroenterology
Manuscript ID	44662
Country	Greece

Received	2018-11-21 02:01
Peer-Review Started	2018-11-22 02:29
To Make the First Decision	2018-12-12 07:59
Return for Revision	2018-12-17 07:00
Revised	2018-12-20 08:22
Second Decision	2019-01-04 09:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-01-15 01:38
Articles in Press	2019-01-15 01:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-01-29 06:57
Publish the Manuscript Online	2019-01-30 05:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Contribution of ghrelin to functional gastrointestinal disorders’ pathogenesis
Manuscript Source	Invited Manuscript
All Author List	Tilemachos Koutouratsas, Theodora Kalli, Georgios Karamanolis and Maria Gazouli
Funding Agency and Grant Number
Corresponding Author	Maria Gazouli, PhD, Associate Professor, Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Michalakopoulou 176, Athens 11527, Greece. mgazouli@med.uoa.gr
Key Words	Functional gastrointestinal disorders; Functional colonic diseases; Irritable bowel syndrome; Cyclic vomiting syndrome; Infantile colic; Gastrointestinal disease; Ghrelin; Genetics; Epigenetic processes
Core Tip	Functional gastrointestinal disorders are diverse clinical entities whose pathogenesis and phenotype are thought to stem from both genetic and environmental factors. Many reviews have attempted to summarize general pathogenetic mechanisms related to functional gastrointestinal disorders (FGIDs), but more specific knowledge is currently limited. Studies on the brain-gut axis peptide ghrelin have chiefly concentrated on its association with obesity and eating disorders. This review focuses on the possible role of ghrelin in FGID pathogenesis, in an attempt to elucidate the contribution of certain genetic alterations to the emergence of disease.
Publish Date	2019-01-30 05:59
Citation	Koutouratsas T, Kalli T, Karamanolis G, Gazouli M. Contribution of ghrelin to functional gastrointestinal disorders' pathogenesis. World J Gastroenterol 2019; 25(5): 539-551
URL	https://www.wjgnet.com/1007-9327/full/v25/i5/539.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i5.539

Full Article (PDF)	WJG-25-539.pdf
Full Article (Word)	WJG-25-539.docx
Manuscript File	44662-Review.docx
Answering Reviewers	44662-Answering reviewers.pdf
Audio Core Tip	44662-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	44662-Conflict-of-interest statement.pdf
Copyright License Agreement	44662-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	44662-Language certificate.pdf
Peer-review Report	44662-Peer-review(s).pdf
Scientific Misconduct Check	44662-Scientific misconduct check.pdf
Scientific Editor Work List	44662-Scientific editor work list.pdf