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1/27/2019 7:53:50 AM | Browse: 50 | Download: 26
Publication Name World Journal of Gastroenterology
Manuscript ID 44883
Country of Manuscript Source United States
Received
2018-11-30 01:33
Peer-Review Started
2018-11-30 05:48
To Make the First Decision
2019-01-11 06:32
Return for Revision
2019-01-11 07:48
Revised
2019-01-15 17:06
Second Decision
2019-01-18 11:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-18 23:11
Articles in Press
2019-01-18 23:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-01-25 02:12
Publish the Manuscript Online
2019-01-26 11:40
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Review
Article Title Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression
Manuscript Source Invited Manuscript
All Author List Murali Ganesan, Larisa Y Poluektova, Kusum K Kharbanda and Natalia A Osna
Funding Agency and Grant Number
Funding Agency Grant Number
NIH-NIAAA K01AA026864
Correspondence To Murali Ganesan, PhD, Instructor, Instructor, Research Service (151), Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Ave, Omaha, NE68105, United States. murali.ganesan@unmc.edu
Keywords Human immunodeficiency virus; Hepatitis C virus; Hepatitis B virus; Fibrosis; Stiffness; Treatment
Core Tip In this review, we summarized the literature and our recent findings on liver damage associated with co-infection with human immunodeficiency virus (HIV) and hepatotropic viruses [hepatitis C virus (HCV), hepatitis B virus (HBV)]. The combination of HIV with HCV or HBV causes progressive liver injury and chronic liver inflammation ultimately leading to end-stage liver disease, such as cirrhosis and hepatocellular carcinoma. These outcomes are related to many events including apoptosis-mediated cross-talk between liver parenchymal and non-parenchymal cells, accumulation of inflammatory cells in the liver, microbial translocation and impaired immune responses. The treatment of these co-infections requires the combination of direct acting antiviral (DAA) and antiretroviral therapy (ART) for HCV+HIV and comparatively high doses of DAA for HBV, which should be controlled for drug-drug interactions to avoid hepatotoxicity.
Publish Date 2019-01-26 11:40
Citation Ganesan M, Poluektova LY, Kharbanda KK, Osna NA. Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression. World J Gastroenterol 2019; 25(4): 398-410
Url https://www.wjgnet.com/1007-9327/full/v25/i4/398.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i4.398
Full Article (PDF) WJG-25-398.pdf
Full Article (Word) WJG-25-398.docx
Peer-review Report 44883-Peer-review(s).pdf
Scientific Misconduct Check 44883-Scientific misconduct check.pdf
Scientific Editor Work List 44883-Scientific editor work list.pdf