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Publication Name World Journal of Clinical Oncology
Manuscript ID 44886
Country/Territory India
2018-12-02 06:04
Peer-Review Started
2018-12-03 00:42
To Make the First Decision
2019-01-02 01:12
Return for Revision
2019-01-08 06:30
2019-01-25 09:49
Second Decision
2019-02-26 08:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-02-28 07:34
Articles in Press
2019-02-28 07:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-04-24 08:33
Publish the Manuscript Online
2019-04-24 15:39
ISSN 2218-4333 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Study
Article Title Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3β/ β-catenin in urinary bladder cancer patients
Manuscript Source Invited Manuscript
All Author List Niharika Maurya, Rinni Singh, Apul Goel, Atin Singhai, Uday Pratap Singh, Vinita Agrawal and Minal Garg
Funding Agency and Grant Number
Funding Agency Grant Number
Department of Science and Technology, Govt. of India SR/SO/HS-0113/2010
Corresponding author Minal Garg, MSc, PhD, Assistant Professor, Department of Biochemistry, Lucknow University, Lucknow 226007, India. minal14@yahoo.com
Keywords Pathobiology; Target genes; Tumor stage and grade; Wnt/β–catenin signal cascade; Urothelial carcinoma of bladder
Core Tip Aberrant co-expression of phosphorylated form of glycogen synthase kinase-3β (pS9GSK-3β) and β–catenin proteins and their association with tumor stage, tumor type, smoking/tobacco chewing status and shorter overall survival probabilities of urinary bladder cancer patients validate them as potential markers of diagnostic/prognostic significance in disease pathogenesis. Observed histopathological association of nuclear Cyclin D1 identifies it as a marker of potential relevance in tumors with altered pS9GSK-3β/β-catenin proteins. These results rule out the possible post translational activation of target genes examined, by pS9GSK-3β/β-catenin/T-cell factor/lymphoid enhancer factor transcriptional complex in bladder tumorigenesis.
Publish Date 2019-04-24 15:39
Citation Maurya N, Singh R, Goel A, Singhai A, Singh UP, Agrawal V, Garg M. Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3β/ β-catenin in urinary bladder cancer patients. World J Clin Oncol 2019; 10(4): 166-182
Url https://www.wjgnet.com/2218-4333/full/v10/i4/166.htm
DOI https://dx.doi.org/10.5306/wjco.v10.i4.166
Full Article (PDF) WJCO-10-166.pdf
Full Article (Word) WJCO-10-166.docx
Manuscript File 44886-Review.docx
Answering Reviewers 44886-Answering reviewers.pdf
Audio Core Tip 44886-Audio core tip.mp3
Biostatistics Review Certificate 44886-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 44886-Conflict-of-interest statement.pdf
Copyright License Agreement 44886-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 44886-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 44886-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 44886-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 44886-Language certificate.pdf
Peer-review Report 44886-Peer-review(s).pdf
Scientific Misconduct Check 44886-Scientific misconduct check.pdf
Scientific Editor Work List 44886-Scientific editor work list.pdf