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5/8/2019 2:09:16 AM | Browse: 585 | Download: 1000
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Received |
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2018-12-11 01:52 |
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Peer-Review Started |
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2018-12-11 09:31 |
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To Make the First Decision |
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2019-01-14 01:05 |
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Return for Revision |
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2019-01-27 01:16 |
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Revised |
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2019-02-23 00:01 |
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Second Decision |
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2019-03-15 09:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-03-16 14:36 |
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Articles in Press |
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2019-03-16 14:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-03-31 20:37 |
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Typeset the Manuscript |
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2019-04-24 05:55 |
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Publish the Manuscript Online |
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2019-04-26 03:39 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Francielle Graus-Nunes, Felipe de Oliveira Santos, Thatiany de Souza Marinho, Carolline Santos Miranda, Sandra Barbosa-da-Silva and Vanessa Souza-Mello |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundação Carlos Chagas Filho de Apoio à Pesquisa do Estado do Rio de Janeiro (FAPERJ |
E-26/202.888/2015 |
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| Corresponding Author |
Vanessa Souza-Mello, PhD, Adjunct Professor, Laboratório de Morfometria, Metabolismo e Doenças Cardiovasculares, Departamento de Anatomia, Instituto de Biologia Roberto Alcântara Gomes, Av. 28 de setembro 87 fundos, Rio de Janeiro 20551-030, Brazil. v.souzamello@gmail.com |
| Key Words |
Liver; Telmisartan; Losartan; Obesity; Angiotensin II type 1 receptor; C57BL/6 mouse |
| Core Tip |
Studies that address the modulation of local renin-angiotensin system (RAS) have gathered pace as it was established that obese subjects exhibit overexpression of the components of classical RAS in organs like the liver. Herein we show pieces of evidence that two different angiotensin II receptor blockers can modulate the intrahepatic RAS, with favored angiotensin-converting enzyme (ACE) 2/rMAS axis over ACE1/angiotensin II type 1 receptor in mice fed a high-fat diet. These actions could mitigate hepatic steatosis through reduced hepatic triacylglycerol levels along with decreased body mass and better glycemic control. These drugs could be a viable option to treat non-alcoholic fatty liver disease in obese and/or hypertensive patients. |
| Publish Date |
2019-04-26 03:39 |
| Citation |
Graus-Nunes F, Santos FO, Marinho TS, Miranda CS, Barbosa-da-Silva S, Souza-Mello V. Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model. World J Hepatol 2019; 11(4): 359-369 |
| URL |
https://www.wjgnet.com/1948-5182/full/v11/i4/359.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v11.i4.359 |
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