Publication Name	World Journal of Hepatology
Manuscript ID	45655
Country	United States

Received	2019-01-16 01:32
Peer-Review Started	2019-01-17 10:36
To Make the First Decision	2019-02-18 01:45
Return for Revision	2019-03-05 01:27
Revised	2019-06-05 13:53
Second Decision	2019-06-14 08:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-06-17 21:00
Articles in Press	2019-06-17 21:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-06-23 19:41
Typeset the Manuscript	2019-06-27 08:27
Publish the Manuscript Online	2019-06-27 10:40

ISSN	1948-5182 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients
Manuscript Source	Unsolicited Manuscript
All Author List	Matthew Fasullo, Prashanth Rau, Dong-Qi Liu, Erik Holzwanger, Jomol P Mathew, Yurima Guilarte-Walker and Gyongyi Szabo
Funding Agency and Grant Number
Corresponding Author	Gyongyi Szabo, MD, N/A, PhD, Doctor, Doctor, Professor, Department of Medicine, University of Massachusetts Medical School, 364 Planation Street, Worcester, MA 01605, United States. gyongyi.szabo@umassmed.edu
Key Words	Cirrhosis; Hepatic encephalopathy; Proton pump inhibitors; Hepatology; Proton pump inhibitor
Core Tip	In this study, we investigate if proton pump inhibitors (PPIs) use in patients with hepatic encephalopathy (HE) predisposes them to more severe stages of HE as per West Haven Criteria. We found that chronic PPI use in cirrhotic patients is associated with significantly higher average West Haven Criteria for HE as compared to patients with no PPI. Our data also indicated that cirrhotic patients on PPI have longer hospital stays, with increased morbidity and mortality during hospital stays.
Publish Date	2019-06-27 10:40
Citation	Fasullo M, Rau P, Liu DQ, Holzwanger E, Mathew JP, Guilarte-Walker Y, Szabo G. Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients. World J Hepatol 2019; 11(6): 522-530
URL	https://www.wjgnet.com/1948-5182/full/v11/i6/522.htm
DOI	https://dx.doi.org/10.4254/wjh.v11.i6.522

Full Article (PDF)	WJH-11-522.pdf
Full Article (Word)	WJH-11-522.docx
Manuscript File	FP6882_de26_CE1MS-edit2.docx
Answering Reviewers	45655-Answering reviewers.pdf
Audio Core Tip	45655-Audio core tip.mp3
Biostatistics Review Certificate	45655-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	45655-Conflict-of-interest statement.pdf
Copyright License Agreement	45655-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	45655-Institutional review board statement.pdf
Peer-review Report	45655-Peer-review(s).pdf
Scientific Misconduct Check	45655-Scientific misconduct check.pdf
Scientific Editor Work List	45655-Scientific editor work list.pdf
CrossCheck Report	45655-CrossCheck Report.pdf