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6/28/2019 8:01:23 AM | Browse: 67 | Download: 66
Publication Name World Journal of Hepatology
Manuscript ID 45655
Country of Manuscript Source United States
Received
2019-01-16 01:32
Peer-Review Started
2019-01-17 10:36
To Make the First Decision
2019-02-18 01:45
Return for Revision
2019-03-05 01:27
Revised
2019-06-05 13:53
Second Decision
2019-06-14 08:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-17 21:00
Articles in Press
2019-06-17 21:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-06-23 19:41
Typeset the Manuscript
2019-06-27 08:27
Publish the Manuscript Online
2019-06-27 10:40
ISSN 1948-5182 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients
Manuscript Source Unsolicited Manuscript
All Author List Matthew Fasullo, Prashanth Rau, Dong-Qi Liu, Erik Holzwanger, Jomol P Mathew, Yurima Guilarte-Walker and Gyongyi Szabo
Funding Agency and Grant Number
Correspondence To Gyongyi Szabo, MD, N/A, PhD, Doctor, Professor, Department of Medicine, University of Massachusetts Medical School, 364 Planation Street, Worcester, MA01605, United States. Gyongyi.Szabo@umassmed.edu
Keywords Cirrhosis; Hepatic encephalopathy; Proton pump inhibitors; Hepatology; Proton pump inhibitor
Core Tip In this study, we investigate if proton pump inhibitors (PPIs) use in patients with hepatic encephalopathy (HE) predisposes them to more severe stages of HE as per West Haven Criteria. We found that chronic PPI use in cirrhotic patients is associated with significantly higher average West Haven Criteria for HE as compared to patients with no PPI. Our data also indicated that cirrhotic patients on PPI have longer hospital stays, with increased morbidity and mortality during hospital stays.
Publish Date 2019-06-27 10:40
Citation Fasullo M, Rau P, Liu DQ, Holzwanger E, Mathew JP, Guilarte-Walker Y, Szabo G. Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients. World J Hepatol 2019; 11(6): 522-530
Url https://www.wjgnet.com/1948-5182/full/v11/i6/522.htm
DOI https://dx.doi.org/10.4254/wjh.v11.i6.522
Full Article (PDF) WJH-11-522.pdf
Full Article (Word) WJH-11-522.docx
Manuscript File FP6882_de26_CE1MS-edit2.docx
Answering Reviewers 45655-Answering reviewers.pdf
Audio Core Tip 45655-Audio core tip.mp3
Biostatistics Review Certificate 45655-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 45655-Conflict-of-interest statement.pdf
Copyright License Agreement 45655-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 45655-Institutional review board statement.pdf
Peer-review Report 45655-Peer-review(s).pdf
Scientific Misconduct Check 45655-Scientific misconduct check.pdf
Scientific Editor Work List 45655-Scientific editor work list.pdf