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4/23/2019 9:03:59 AM | Browse: 90 | Download: 56
Publication Name World Journal of Gastroenterology
Manuscript ID 45847
Country of Manuscript Source Argentina
Received
2019-01-18 00:36
Peer-Review Started
2019-01-18 07:47
To Make the First Decision
2019-03-20 06:46
Return for Revision
2019-03-21 07:01
Revised
2019-03-21 15:57
Second Decision
2019-03-29 10:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-30 00:46
Articles in Press
2019-03-30 00:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-04-17 00:56
Publish the Manuscript Online
2019-04-18 05:48
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Opinion Review
Article Title Repurposing drugs to target nonalcoholic steatohepatitis
Manuscript Source Invited Manuscript
All Author List Silvia Sookoian and Carlos J Pirola
Funding Agency and Grant Number
Funding Agency Grant Number
Agencia Nacional de Promoción Científica y Tecnológica, FONCyT PICT 2014-0432
Agencia Nacional de Promoción Científica y Tecnológica, FONCyT PICT 2014-1816
Agencia Nacional de Promoción Científica y Tecnológica, FONCyT PICT 2015-0551
Agencia Nacional de Promoción Científica y Tecnológica, FONCyT PICT 2016-0135
Correspondence To Silvia Sookoian, FAASLD, MD, PhD, Senior Scientist, Department of Clinical and Molecular Hepatology, National Scientific and Technical Research Council (CONICET), University of Buenos Aires, Institute of Medical Research (IDIM), Combatientes de Malvinas 3150, Ciudad Autónoma de Buenos Aires 1427, Argentina. ssookoian@intramed.net
Keywords Drug discovery; Drug repositioning; Fibrosis; Genetics; Treatment; Systems biology
Core Tip As a proof-of-concept of the advantages that can be yielded by applying multi-omics systems-based approaches to the analysis of potential candidates to the treatment of nonalcoholic steatohepatitis (NASH) we selected the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway map of nonalcoholic fatty liver disease (NAFLD), which illustrates a stage-dependent progression of the disease. After generating a protein−chemical interaction network, we predicted remarkable examples of potential drug repurposing for the treatment of NASH based on the NAFLD-KEGG connectivity map.
Publish Date 2019-04-18 05:48
Citation Sookoian S, Pirola CJ. Repurposing drugs to target nonalcoholic steatohepatitis. World J Gastroenterol 2019;25(15): 1783-1796
Url https://www.wjgnet.com/1007-9327/full/v25/i15/1783.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i15.1783
Full Article (PDF) WJG-25-1783.pdf
Full Article (Word) WJG-25-1783.docx
Manuscript File 45847-Review.doc
Answering Reviewers 45847-Answering reviewers.pdf
Audio Core Tip 45847-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 45847-Conflict-of-interest statement.pdf
Copyright License Agreement 45847-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 45847-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 45847-Language certificate.pdf
Peer-review Report 45847-Peer-review(s).pdf
Scientific Misconduct Check 45847-Scientific misconduct check.pdf
Scientific Editor Work List 45847-Scientific editor work list.pdf