Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	46230
Country	Taiwan

Received	2019-03-15 03:09
Peer-Review Started	2019-03-18 00:19
To Make the First Decision	2019-06-05 06:34
Return for Revision	2019-06-06 03:45
Revised	2019-07-05 05:51
Second Decision	2019-08-16 08:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-19 03:14
Articles in Press	2019-08-19 03:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-08 03:49
Publish the Manuscript Online	2019-09-12 10:38

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Tumor progression-dependent angiogenesis in gastric cancer and its potential application
Manuscript Source	Invited Manuscript
All Author List	Ming-Ming Tsai and Hsi-Lung Hsieh
Funding Agency and Grant Number
Corresponding Author	Ming-Ming Tsai, PhD, Associate Professor, Department of Nursing, Division of Basic Medical Sciences,, Chang-Gung University of Science and Technology, 261 Wen-hwa 1 Road, Taoyuan 333, Taiwan. mmtsai@mail.cgust.edu.tw
Key Words	Gastric cancer; Angiogenesis; Vascular endothelial cell; Angiogenic phenotype switch; Anti-angiogenesis; Tumor dormancy
Core Tip	Tumor angiogenesis in GC and anti-angiogenic therapies for GC, including information from their preclinical to clinical trials and/or application, are discussed. The anti-angiogenic strategies include decreasing the expression of pro-angiogenic ligands and their receptors, increasing the level of angiogenic inhibitors, the direct targeting of the inner walls of ECs, and the administration of cell-cell adhesion inhibitors for advanced GC. This review provides a brief description of various tumor angiogenic factors for the purposes of diagnosis, prognosis and therapeutics and describes the anti-angiogenic drugs that are currently being investigated in preclinical and clinical trials. Hopefully, based on the molecular mechanism of tumor angiogenesis, we highlight the accuracy of diagnosis and prognosis and the selection of the most appropriate therapy for GC patients.
Publish Date	2019-09-12 10:38
Citation	Hsieh HL, Tsai MM. Tumor progression-dependent angiogenesis in gastric cancer and its potential application. World J Gastrointest Oncol 2019; 11(9): 686-704
URL	https://www.wjgnet.com/1948-5204/full/v11/i9/686.htm
DOI	https://dx.doi.org/10.4251/wjgo.v11.i9.686

Full Article (PDF)	WJGO-11-686.pdf
Full Article (Word)	WJGO-11-686.docx
Manuscript File	46230-Review.docx
Answering Reviewers	46230-Answering reviewers.pdf
Audio Core Tip	46230-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	46230-Conflict-of-interest statement.pdf
Copyright License Agreement	46230-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	46230-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	46230-Language certificate.pdf
Peer-review Report	46230-Peer-review(s).pdf
Scientific Misconduct Check	46230-Scientific misconduct check.pdf
Scientific Editor Work List	46230-Scientific editor work list.pdf