Publication Name	World Journal of Diabetes
Manuscript ID	46296
Country	Jordan

Received	2019-02-06 03:03
Peer-Review Started	2019-02-10 14:42
To Make the First Decision	2019-02-20 00:34
Return for Revision	2019-02-21 04:25
Revised	2019-03-08 20:08
Second Decision	2019-03-12 09:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-03-12 23:10
Articles in Press	2019-03-12 23:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-03-14 09:09
Publish the Manuscript Online	2019-03-15 07:18

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Case Control Study
Article Title	Screening the RFX6-DNA binding domain for potential genetic variants in patients with type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Ismail Sami Mahmoud, Ayat Homsi, Hamzeh Al-Ameer, Jihad Alzyoud, Mais Darras, Mohammad Al Shhab, Malek Zihlif, Ma’mon Hatmal and Walhan Alshaer
Funding Agency and Grant Number
Corresponding Author	Ismail Sami Mahmoud, PhD, Doctor, Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, The Hashemite University, Zarqa 13133, Jordan. ismails@hu.edu.jo
Key Words	Regulatory factor X6; Genetic variant; Diabetes; DNA binding domain
Core Tip	Regulatory Factor X6 (RFX6) protein plays a key role in the differentiation of pancreatic beta cells as well as insulin production and secretion. Several lines of evidence have indicated that RFX6 binding to DNA could be disrupted in diabetes; however, the mechanism underlying this process is still unknown. In this case-control study, we analysed the genotype of RFX6-DNA binding domain in diabetes patients in comparison to healthy controls. Our results indicate the absence of any significant genetic variant in the DNA binding domain that could affect the function of RFX6 in type 2 diabetes.
Publish Date	2019-03-15 07:18
Citation	Mahmoud IS, Homsi A, Al-Ameer HJ, Alzyoud J, Darras M, Shhab MA, Zihlif M, Hatmal MM, Alshaer W. Screening the RFX6-DNA binding domain for potential genetic variants in patients with type 2 diabetes. World J Diabetes 2019; 10(3): 181-188
URL	https://www.wjgnet.com/1948-9358/full/v10/i3/181.htm
DOI	https://dx.doi.org/10.4239/wjd.v10.i3.181

Full Article (PDF)	WJD-10-181.pdf
Full Article (Word)	WJD-10-181.docx
STROBE Statement	46296-STROBE-Statement-revision.pdf
Manuscript File	46296-Review.docx
Answering Reviewers	46296-Answering reviewers.pdf
Audio Core Tip	46296-Audio core tip.m4a
Biostatistics Review Certificate	46296-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	46296-Conflict-of-interest statement.pdf
Copyright License Agreement	46296-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	46296-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	46296-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	46296-Language certificate.pdf
Peer-review Report	46296-Peer-review(s).pdf
Scientific Misconduct Check	46296-Scientific misconduct check.pdf
Scientific Editor Work List	46296-Scientific editor work list.pdf