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8/26/2019 8:57:46 AM | Browse: 65 | Download: 46
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 46385
Country of Manuscript Source United States
Received
2019-02-14 01:02
Peer-Review Started
2019-02-15 02:16
To Make the First Decision
2019-03-18 06:09
Return for Revision
2019-03-28 01:20
Revised
2019-04-02 17:58
Second Decision
2019-05-22 08:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-23 17:00
Articles in Press
2019-05-23 17:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-05-29 19:34
Typeset the Manuscript
2019-08-15 05:56
Publish the Manuscript Online
2019-08-16 00:41
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript type Basic Study
Article Title SFRP4 expression correlates with epithelial mesenchymal transition-linked genes and poor overall survival in colon cancer patients
Manuscript Source Unsolicited Manuscript
All Author List Landry Nfonsam, Jana Jandova, Hunter Jecius, Pamela N Omesiete and Valentine N Nfonsam
Funding Agency and Grant Number
Funding Agency Grant Number
SAGES
Correspondence To Valentine N Nfonsam, BSc, FACS, MD, MSc, Associate Professor, Surgeon, Surgical Oncologist, Program Director, Department of Surgery, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, United States. vnfonsam@surgery.arizona.edu
Keywords Secreted frizzled-related protein 4; Epithelial mesenchymal transition, Colon cancer; Survival; ; ;
Core Tip We have previously showed that secreted frizzled-related protein 4 (SFRP4) is over-expressed in colon cancer, especially in patients younger than 50 years. As these early-onset colon cancers tent to be more aggressive and negatively affecting patients’ survival, we sought to evaluate whether SFRP4 is co-expressed with epithelial-mesenchymal transition-linked genes that play key roles in cancer progression. Our results using a large colon adenocarcinoma-The Cancer Genome Atlas cohort revealed that SFRP4 is over-expressed in colon cancer patients together with epithelial-mesenchymal transition-linked genes. Moreover, colon cancer patients with high expression levels of SFRP4 showed significantly poorer survival relative to colon cancer patients with lower SFRP4 expression.
Publish Date 2019-08-16 00:41
Citation Nfonsam LE, Jandova J, Jecius HC, Omesiete PN, Nfonsam VN. SFRP4 expression correlates with epithelial mesenchymal transition-linked genes and poor overall survival in colon cancer patients. World J Gastrointest Oncol 2019; 11(8): 589-598
Url https://www.wjgnet.com/1948-5204/full/v11/i8/589.htm
DOI https://dx.doi.org/10.4251/wjgo.v11.i8.589
Full Article (PDF) WJGO-11-589.pdf
Full Article (Word) WJGO-11-589.docx
Manuscript File FP6871_de5_CE1MS-edit2.doc
Answering Reviewers 46385-Answering reviewers.pdf
Audio Core Tip 46385-Audio core tip.m4a
Biostatistics Review Certificate 46385-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46385-Conflict-of-interest statement.pdf
Copyright License Agreement 46385-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46385-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 46385-Institutional Animal Care and Use Committee Approval Form or Document.pdf
Institutional Review Board Approval Form or Document 46385-Institutional review board statement.pdf
Peer-review Report 46385-Peer-review(s).pdf
Scientific Misconduct Check 46385-Scientific misconduct check.pdf
Scientific Editor Work List 46385-Scientific editor work list.pdf