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8/26/2019 8:57:46 AM | Browse: 699 | Download: 953
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Received |
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2019-02-14 01:02 |
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Peer-Review Started |
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2019-02-15 02:16 |
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To Make the First Decision |
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2019-03-18 06:09 |
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Return for Revision |
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2019-03-28 01:20 |
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Revised |
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2019-04-02 17:58 |
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Second Decision |
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2019-05-22 08:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-05-23 17:00 |
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Articles in Press |
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2019-05-23 17:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-05-29 19:34 |
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Typeset the Manuscript |
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2019-08-15 05:56 |
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Publish the Manuscript Online |
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2019-08-16 00:41 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
SFRP4 expression correlates with epithelial mesenchymal transition-linked genes and poor overall survival in colon cancer patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Landry Nfonsam, Jana Jandova, Hunter Jecius, Pamela N Omesiete and Valentine N Nfonsam |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| SAGES |
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| Corresponding Author |
Valentine N Nfonsam, BSc, FACS, MD, MSc, Associate Professor, Surgeon, Surgical Oncologist, Department of Surgery, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, United States. vnfonsam@surgery.arizona.edu |
| Key Words |
Secreted frizzled-related protein 4; Epithelial mesenchymal transition, Colon cancer; Survival; ; ; |
| Core Tip |
We have previously showed that secreted frizzled-related protein 4 (SFRP4) is over-expressed in colon cancer, especially in patients younger than 50 years. As these early-onset colon cancers tent to be more aggressive and negatively affecting patients’ survival, we sought to evaluate whether SFRP4 is co-expressed with epithelial-mesenchymal transition-linked genes that play key roles in cancer progression. Our results using a large colon adenocarcinoma-The Cancer Genome Atlas cohort revealed that SFRP4 is over-expressed in colon cancer patients together with epithelial-mesenchymal transition-linked genes. Moreover, colon cancer patients with high expression levels of SFRP4 showed significantly poorer survival relative to colon cancer patients with lower SFRP4 expression. |
| Publish Date |
2019-08-16 00:41 |
| Citation |
Nfonsam LE, Jandova J, Jecius HC, Omesiete PN, Nfonsam VN. SFRP4 expression correlates with epithelial mesenchymal transition-linked genes and poor overall survival in colon cancer patients. World J Gastrointest Oncol 2019; 11(8): 589-598 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i8/589.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i8.589 |
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