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11/15/2019 9:25:09 AM | Browse: 184 | Download: 161
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 46682
Country/Territory China
2019-02-21 01:27
Peer-Review Started
2019-02-22 09:15
To Make the First Decision
2019-08-01 00:00
Return for Revision
2019-08-09 01:15
2019-08-18 02:08
Second Decision
2019-09-19 01:56
Accepted by Journal Editor-in-Chief
2019-09-19 10:56
Accepted by Company Editor-in-Chief
2019-09-26 21:54
Articles in Press
2019-09-26 21:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-11-06 07:28
Publish the Manuscript Online
2019-11-15 07:45
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Endothelial cells in colorectal cancer
Manuscript Source Invited Manuscript
All Author List Wu-Zhen Chen, Jing-Xin Jiang, Xiu-Yan Yu, Wen-Jie Xia, Peng-Xin Yu, Ke Wang, Zhi-Yong Zhao and Zhi-Gang Chen
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China (NO. 81502564 and 81703498)
the Natural Science Foundation of Zhejiang province (NO. LY16H160018, LY18H160001)
China Scholarship Council (CSC) NO. 201706325003
Corresponding author Zhi-Gang Chen, MD, PhD, Assistant Professor, Surgeon, Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Zheda Road, Hangzhou 310000, Zhejiang Province, China. chenzhigang@zju.edu.cn
Keywords Colorectal cancer; Tumor-associated endothelial cells; Heterogeneity; Vascular endothelial growth factor; Immune remodeling;
Core Tip In 1971, Folkman highlighted the importance of angiogenesis in tumor growth. The key events involved in this process are endothelial cell proliferation, migration, and vascular formation. Recent studies have revealed the importance of tumor-associated endothelial cells (TECs) in the development and progression of colorectal cancer (CRC). However, few systematically reviewed the role of TECs in CRC. Our objective is to compare the characteristics of normal endothelial cells and TECs, review the role of TECs in the stages of CRC, and discuss the possibility of TECs to serve as a biomarker to predict the prognosis and a potential therapeutic target.
Publish Date 2019-11-15 07:45
Citation Chen WZ, Jiang JX, Yu XY, Xia WJ, Yu PX, Wang K, Zhao ZY, Chen ZG. Endothelial cells in colorectal cancer. World J Gastrointest Oncol 2019; 11(11): 946-956
Url https://www.wjgnet.com/1948-5204/full/v11/i11/946.htm
DOI https://dx.doi.org/10.4251/wjgo.v11.i11.946
Full Article (PDF) WJGO-11-946.pdf
Full Article (Word) WJGO-11-946.docx
Manuscript File 46682-Review.docx
Answering Reviewers 46682-Answering reviewers.pdf
Audio Core Tip 46682-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 46682-Conflict-of-interest statement.pdf
Copyright License Agreement 46682-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46682-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 46682-Language certificate.pdf
Peer-review Report 46682-Peer-review(s).pdf
Scientific Misconduct Check 46682-Journal editor-in-chief review report.pdf
Scientific Editor Work List 46682-Scientific editor work list.pdf