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6/14/2019 6:51:09 AM | Browse: 77 | Download: 42
Publication Name World Journal of Gastroenterology
Manuscript ID 46708
Country of Manuscript Source South Korea
Received
2019-02-21 08:10
Peer-Review Started
2019-02-22 04:54
To Make the First Decision
2019-03-27 03:42
Return for Revision
2019-03-28 02:22
Revised
2019-04-12 12:40
Second Decision
2019-04-19 07:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-04-20 01:59
Articles in Press
2019-04-20 01:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-05-25 07:12
Publish the Manuscript Online
2019-05-28 09:29
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Changhoon Choi, Gyu Sang Yoo, Won Kyung Cho and Hee Chul Park
Funding Agency and Grant Number
Correspondence To Hee Chul Park, MD, PhD, Full Professor, Professor, Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea. hee.ro.park@samsung.com
Keywords Hepatocellular carcinoma; Radiation therapy; Immune checkpoint inhibitors; Abscopal effect
Core Tip In the era of cancer immunotherapy, the roles of radiation therapy (RT) are not limited to the direct killing of cancerous cells but have expanded to immune modulation. Numerous proof-of-concept preclinical studies have proven that combination approaches of RT and immune checkpoint inhibitors (ICIs) are highly promising for many types of cancers, and currently, many related clinical trials are ongoing. Historically, RT was considered ineffective for hepatocellular carcinoma (HCC), but the efficacy of RT in HCC has improved greatly with technical advances. Our goal of this review is to provide a rationale for the combined treatment with RT and ICIs in HCC.
Publish Date 2019-05-28 09:29
Citation Choi C, Yoo GS, Cho WK, Park HC. Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma. World J Gastroenterol 2019; 25(20): 2416-2429
Url https://www.wjgnet.com/1007-9327/full/v25/i20/2416.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i20.2416
Full Article (PDF) WJG-25-2416.pdf
Full Article (Word) WJG-25-2416.docx
Manuscript File 46708-Review.docx
Answering Reviewers 46708-Answering reviewers.pdf
Audio Core Tip 46708-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 46708-Conflict-of-interest statement.pdf
Copyright License Agreement 46708-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 46708-Language certificate.pdf
Peer-review Report 46708-Peer-review(s).pdf
Scientific Misconduct Check 46708-Google-MA RY-1.png
Scientific Misconduct Check 46708-Google-MA RY-2.png
Scientific Misconduct Check 46708-Scientific misconduct check.pdf
Scientific Editor Work List 46708-Scientific editor work list.pdf